海洋来源的真菌中氨基转移酶家族基因的遗传操作激活了 Youssoufenes。

Genetic Manipulation of an Aminotransferase Family Gene Activates Youssoufenes in Marine-Derived .

机构信息

Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy , Ocean University of China , Qingdao 266003 , China.

Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology , Qingdao 266237 , People's Republic of China.

出版信息

Org Lett. 2020 Jan 17;22(2):729-733. doi: 10.1021/acs.orglett.9b04559. Epub 2019 Dec 31.

DOI:10.1021/acs.orglett.9b04559

PMID:31891272

Abstract

Disruption of an aminotransferase family gene activated the production of a novel dimeric benzoic polyene acids (BPAs), named youssoufene A1 (), along with four new (-, youssoufenes B1-B4) and a known () monomeric BPA in the marine-derived OUC6819. The structures of - were elucidated by extensive spectroscopic and computational approaches. Youssoufene A1 () exhibited notably increased growth inhibition (MIC = 12.5 μg/mL) against multidrug resistant compared to monomeric structures (-).

摘要

海洋来源的 OU C6819 中，一个转氨酶家族基因的失活激活了新型二聚苯甲酸多烯酸（BPAs）的产生，命名为 youssoufene A1（），以及四个新的（-，youssoufenes B1-B4）和一个已知的（）单体 BPA。通过广泛的光谱和计算方法阐明了 - 的结构。与单体结构（-）相比，youssoufene A1（）对多药耐药菌的生长抑制作用显著增强（MIC=12.5μg/mL）。