组蛋白乳酰化：葡萄糖代谢的新作用。
Histone Lactylation: A New Role for Glucose Metabolism.
机构信息
Laboratory of Systems Cancer Biology, The Rockefeller University, New York, NY 10065, USA; Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY 10065, USA.
Morrisville, NC 27560, USA.
出版信息
Trends Biochem Sci. 2020 Mar;45(3):179-182. doi: 10.1016/j.tibs.2019.12.004. Epub 2019 Dec 31.
PMID:31901298
Abstract
Lactate is an end product of glucose metabolism, which serves metabolic and nonmetabolic functions. A new study by Zhang et al. establishes a novel function for lactate whereby it is utilized in a new histone modification, histone lysine lactylation, to regulate gene expression in macrophages.
摘要
乳酸是葡萄糖代谢的终产物，具有代谢和非代谢功能。Zhang 等人的一项新研究确立了乳酸的一个新功能，即它被用于一种新的组蛋白修饰——组蛋白赖氨酸乳酸化，从而调节巨噬细胞中的基因表达。
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