血管紧张素转化酶基因对阿尔茨海默病痴呆患者行为和心理症状的影响。
The Impact of Angiotensin-Converting Enzyme Gene on Behavioral and Psychological Symptoms of Dementia in Alzheimer's Disease.
机构信息
Department of Neurology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
出版信息
Curr Alzheimer Res. 2019;16(14):1269-1275. doi: 10.2174/1567205017666200103114550.
BACKGROUND
The Angiotensin-Converting Enzyme (ACE) gene has drawn attention for its possible role in regulating the degradation of β-amyloid (Aβ), yet its role in affecting the cognitive and psychiatric symptoms of Alzheimer`s Disease (AD) patients has yet to be elucidated.
OBJECTIVE
This study aimed to investigate whether the ACE gene acts as a risk factor of Behavioral and Psychological Symptoms of Dementia (BPSD) in the AD population.
METHODS
The genotyping of ACE and Apolipoprotein E gene with allele ε4(APOEε4) was determined among 360s clinically diagnosed AD patients. Symptoms and severity of BPSD were evaluated annually via Neuropsychiatric Inventory (NPI).
RESULTS
At the base measurement of the first year of patient recruitment, there were no significant contributory risk factors to NPI score. In the two-year follow-up, ACE insertion polymorphism showed a significant risk (adjusted odds ratio=1.65, 95% CI=1.1- 2.5, p=0.019) of progression of NPI total score.
CONCLUSION
ACE gene is involved in aggravating BPSD among AD patients.
背景
血管紧张素转换酶（ACE）基因因其可能在调节β-淀粉样蛋白（Aβ）降解中的作用而受到关注，但它在影响阿尔茨海默病（AD）患者的认知和精神症状方面的作用尚未阐明。
目的
本研究旨在探讨 ACE 基因是否作为 AD 人群行为和心理症状的痴呆（BPSD）的危险因素。
方法
对 360 例临床诊断为 AD 的患者进行 ACE 和载脂蛋白 E 基因等位基因 ε4（APOEε4）的基因分型。通过神经精神问卷（NPI）每年评估 BPSD 的症状和严重程度。
结果
在患者招募的第一年的基础测量中，NPI 评分没有显著的致病危险因素。在两年的随访中，ACE 插入多态性显示 NPI 总分进展的显著风险（调整后的优势比=1.65，95%可信区间=1.1-2.5，p=0.019）。
结论
ACE 基因参与加重 AD 患者的 BPSD。
Zotero 插件