与孕期大麻暴露相关的出生和早期发育筛查结局。
Birth and early developmental screening outcomes associated with cannabis exposure during pregnancy.
机构信息
HealthPartners Institute, Bloomington, MN, USA.
Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
出版信息
J Perinatol. 2020 Mar;40(3):473-480. doi: 10.1038/s41372-019-0576-6. Epub 2020 Jan 7.
OBJECTIVE
To compare birth and early developmental screening outcomes for infants with and without in utero cannabis exposures.
STUDY DESIGN
Observational cohort of women receiving prenatal care within a large health system, live birth between October 1, 2015 and December 1, 2017, and at least one infant visit. Cannabis exposure was through routine urine toxicology screen. Preterm birth, small for gestational age (SGA) birth, birth defects, and early developmental screening outcomes were assessed from birth and electronic health record data.
RESULTS
Of 3435 women, 283 (8.2%) had a positive urine toxicology screen. In utero cannabis exposure was associated with SGA birth, adjusted rate ratio (aRR) 1.69 (95% confidence interval [CI]: 1.22-2.34). Abnormal 12-month developmental screens occurred in 9.1% of infants with in utero cannabis exposure vs. 3.6% of those with negative maternal screens, aRR 1.90 (95% CI: 0.92-3.91). Additional birth outcomes were not associated with in utero cannabis exposure.
CONCLUSIONS
Exposure to cannabis during pregnancy may adversely impact fetal growth.
目的
比较有和无子宫内大麻暴露的婴儿的出生和早期发育筛查结果。
研究设计
在一个大型医疗系统中接受产前护理的女性的观察性队列，活产于 2015 年 10 月 1 日至 2017 年 12 月 1 日之间，且至少有一次婴儿就诊。大麻暴露是通过常规尿液毒理学筛查。从出生和电子健康记录数据评估早产、小于胎龄儿（SGA）出生、出生缺陷和早期发育筛查结果。
结果
在 3435 名女性中，有 283 名（8.2%）尿液毒理学筛查阳性。子宫内大麻暴露与 SGA 出生相关，调整后的比率比（aRR）为 1.69（95%置信区间[CI]：1.22-2.34）。有子宫内大麻暴露的婴儿在 12 个月时出现发育异常筛查的比例为 9.1%，而母亲尿液筛查阴性的婴儿为 3.6%，aRR 为 1.90（95% CI：0.92-3.91）。其他出生结局与子宫内大麻暴露无关。
结论
怀孕期间接触大麻可能对胎儿生长产生不利影响。
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