Departamento de Nutrição e Saúde, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.
Obes Rev. 2020 Jun;21(6):e13000. doi: 10.1111/obr.13000. Epub 2020 Jan 16.
Advanced glycation end products (AGEs) have been implicated in the pathogenesis of most chronic diseases. Therefore, identification of treatments that can attenuate the effects of these compounds and prevent cardiometabolic complications is of extreme public health interest. Recently, body weight management interventions showed positive results on reducing serum AGE concentrations. Moreover, the soluble receptor for advanced glycation end products (sRAGE) is considered to be a novel biomarker to identify patients with obesity most likely to benefit from weight management interventions. This systematic review aimed to critically analyze papers evaluating the effects of weight loss on serum AGEs and its receptors in adults with excess body weight. MEDLINE, Cochrane, Scopus, and Lilacs databases were searched. Three studies evaluating the response of AGEs to energy-restricted diets and six assessing sRAGE as the primary outcome were included. Energy-restricted diets and bariatric surgery reduced serum AGE concentrations, but effects on endogenous secretory RAGE (esRAGE) and sRAGE concentrations are conflicting. These results may be associated with mechanisms related to changes in dietary intake and limiting endogenous AGE formation. Therefore, the role of energy-restricted diets and bariatric surgery on lowering serum AGE concentrations, as well as its effects on AGEs receptors, deserves further investigation.
糖基化终产物（AGEs）与大多数慢性疾病的发病机制有关。因此，寻找可以减轻这些化合物影响并预防心脏代谢并发症的治疗方法具有极高的公共卫生意义。最近，体重管理干预措施在降低血清 AGE 浓度方面显示出积极的效果。此外，糖基化终产物的可溶性受体（sRAGE）被认为是一种新型生物标志物，可以识别出最有可能受益于体重管理干预的肥胖患者。本系统评价旨在批判性地分析评估减肥对超重成年人血清 AGEs 及其受体影响的论文。检索了 MEDLINE、Cochrane、Scopus 和 Lilacs 数据库。纳入了三项评估能量限制饮食对 AGEs 反应的研究和六项评估 sRAGE 为主要结局的研究。能量限制饮食和减肥手术可降低血清 AGE 浓度，但对内源性分泌型 RAGE（esRAGE）和 sRAGE 浓度的影响存在争议。这些结果可能与与饮食摄入变化和限制内源性 AGE 形成相关的机制有关。因此，需要进一步研究能量限制饮食和减肥手术降低血清 AGE 浓度的作用及其对 AGEs 受体的影响。
