肠道失调中的 LOS
LOS in The Dysbiotic Gut.
机构信息
Gale and Ira Drukier Institute for Children's Health, Weill Cornell Medicine, New York City, NY, USA; Department of Pediatrics, Weill Cornell Medicine, New York City, NY, USA.
Gale and Ira Drukier Institute for Children's Health, Weill Cornell Medicine, New York City, NY, USA; Department of Pediatrics, Weill Cornell Medicine, New York City, NY, USA; Immunology & Microbial Pathogenesis Graduate Program, Weill Cornell Medicine, New York City, NY, USA.
出版信息
Cell Host Microbe. 2020 Jan 8;27(1):11-13. doi: 10.1016/j.chom.2019.12.009.
Abstract
The neonatal gut microbiome undergoes dynamic changes in response to many nutritional and environmental variables. A recent study by Singer et al. in Nature Medicine elucidates several mechanisms to inhibit the expansion of gut-derived pathobionts in a dysbiotic neonatal gut and prevent these pathobionts from disseminating systemically and causing sepsis in neonatal mice.
摘要
新生儿肠道微生物组会对许多营养和环境变量做出动态变化。Singer 等人在《自然医学》杂志上的一项最新研究阐明了几种机制，可以抑制肠道来源的条件致病菌在失调的新生儿肠道中扩张，并防止这些条件致病菌在新生儿小鼠体内全身传播并引起败血症。
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本文引用的文献
1
Preventing dysbiosis of the neonatal mouse intestinal microbiome protects against late-onset sepsis.
Nat Med. 2019 Nov;25(11):1772-1782. doi: 10.1038/s41591-019-0640-y. Epub 2019 Nov 7.
2
Neonatal intestinal dysbiosis in necrotizing enterocolitis.
Mol Med. 2018 Mar 15;24(1):4. doi: 10.1186/s10020-018-0002-0.
3
The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota.
Microbiol Mol Biol Rev. 2017 Nov 8;81(4). doi: 10.1128/MMBR.00036-17. Print 2017 Dec.
4
Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion.
Science. 2017 Aug 11;357(6351):570-575. doi: 10.1126/science.aam9949.
5
Longitudinal development of the gut microbiome and metabolome in preterm neonates with late onset sepsis and healthy controls.
Microbiome. 2017 Jul 12;5(1):75. doi: 10.1186/s40168-017-0295-1.
6
Mechanisms of inflammation-driven bacterial dysbiosis in the gut.
Mucosal Immunol. 2017 Jan;10(1):18-26. doi: 10.1038/mi.2016.75. Epub 2016 Aug 24.
7
Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life.
Cell Host Microbe. 2015 May 13;17(5):690-703. doi: 10.1016/j.chom.2015.04.004.
8
Digestion of Protein in Premature and Term Infants.
J Nutr Disord Ther. 2012 Apr 23;2(3):112. doi: 10.4172/2161-0509.1000112.
9
The immune consequences of preterm birth.
Front Neurosci. 2013 May 21;7:79. doi: 10.3389/fnins.2013.00079. eCollection 2013.
10
Early onset neonatal sepsis: the burden of group B Streptococcal and E. coli disease continues.
Pediatrics. 2011 May;127(5):817-26. doi: 10.1542/peds.2010-2217. Epub 2011 Apr 25.
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