JAK 激酶促使含沙门氏菌的巨噬细胞向 M1/M2 极化方向转变，从而逃避免疫攻击，促进细菌的持续存在。
JAK-ing into M1/M2 Polarization SteErs Salmonella-Containing Macrophages Away from Immune Attack to Promote Bacterial Persistence.
机构信息
University of Pennsylvania School of Veterinary Medicine, Department of Pathobiology, Philadelphia, PA 19104, USA; University of Pennsylvania Perelman School of Medicine, Institute for Immunology, Philadelphia, PA 19104, USA.
出版信息
Cell Host Microbe. 2020 Jan 8;27(1):3-5. doi: 10.1016/j.chom.2019.12.007.
Despite decades of study, the molecular basis for granuloma formation and restriction of chronic pathogens remains murky. Three articles reveal how Salmonella rewires macrophage polarization (Panagi et al. and Gibbs et al.) to shift the balance between M1 and M2 granuloma macrophages and resist TNF-mediated clearance (Pham et al.).
尽管已经研究了几十年，但肉芽肿形成和慢性病原体限制的分子基础仍然不清楚。三篇文章揭示了沙门氏菌如何重新布线巨噬细胞极化（Panagi 等人和 Gibbs 等人），以改变 M1 和 M2 肉芽肿巨噬细胞之间的平衡，并抵抗 TNF 介导的清除（Pham 等人）。
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