Division of Natural Drug Discovery, Institute of Natural Medicine , University of Toyama , 2630 Sugitani , Toyama 930-0194 , Japan.
J Nat Prod. 2020 Feb 28;83(2):385-391. doi: 10.1021/acs.jnatprod.9b00875. Epub 2020 Jan 22.
Phytochemical analysis of the roots of led to the isolation of six new cardenolide glycosides, calosides A-F (-), and five known cardenolides (-). The structures of - were elucidated based on NMR and ECD spectroscopic data interpretation. Caloside D () is the first naturally occurring example of a cardenolide containing a C-8/C-19 oxygen bridge. In turn, calosides E () and F () represent the first naturally occurring 3--cannogenol diglycosides having potent cytotoxicity against the PANC-1 cell line (IC, 0.081 and 0.070 μM, respectively) and HeLa (IC, both 0.17 μM) cells, under normoglycemic conditions.
对 led 的根的植物化学分析导致了六个新的卡烯内酯糖苷，calosides A-F（-）和五个已知的卡烯内酯（-）的分离。基于 NMR 和 ECD 光谱数据解释，-的结构被阐明。Cadoside D（）是第一个含有 C-8/C-19 氧桥的卡烯内酯的天然存在的例子。反过来，calosides E（）和 F（）代表第一个天然存在的 3--cannogenol 二糖苷，对 PANC-1 细胞系（IC，分别为 0.081 和 0.070 μM）和 HeLa（IC，均为 0.17 μM）具有很强的细胞毒性，在正常血糖条件下。
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