弗里德里希共济失调的视觉生活质量与临床和视觉状况的相关性。
Correlation of Visual Quality of Life With Clinical and Visual Status in Friedreich Ataxia.
机构信息
Division of Neurology (PA, AL, DRL), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; and Departments of Neurology (RN-K, LJB), Population Health and Ophthalmology, NYU School of Medicine, Sackler Institute of Graduate Biomedical Sciences, New York, New York.
出版信息
J Neuroophthalmol. 2020 Jun;40(2):213-217. doi: 10.1097/WNO.0000000000000878.
BACKGROUND
The primary objective was to determine the association of patient-reported vision-specific quality of life to disease status and visual function in patients with Friedreich's ataxia (FRDA).
METHODS
Patients with FRDA were assessed with the 25-Item National Eye Institute Visual Functioning Questionnaire (NEI-VFQ-25) along with measures of disease status (ataxia stage) and visual function (low- and high-contrast letter acuity scores). The relations of NEI-VFQ-25 scores to those for disease status and visual function were examined.
RESULTS
Scores for the NEI-VFQ-25 were lower in patients with FRDA (n = 99) compared with published disease-free controls, particularly reduced in a subgroup of FRDA patients with features of early onset, older age, and abnormal visual function.
CONCLUSIONS
The NEI-VFQ-25 captures the subjective component of visual function in patients with FRDA.
背景
本研究的主要目的是确定弗里德里希共济失调症（FRDA）患者的视觉特异性生活质量与疾病状态和视觉功能之间的相关性。
方法
使用 25 项国家眼科研究所视觉功能问卷（NEI-VFQ-25）评估 FRDA 患者，同时评估疾病状态（共济失调阶段）和视觉功能（低对比度和高对比度字母视力评分）。检查了 NEI-VFQ-25 评分与疾病状态和视觉功能评分的关系。
结果
与已发表的无疾病对照组相比，FRDA 患者的 NEI-VFQ-25 评分较低（n=99），特别是在 FRDA 患者亚组中，这些患者具有早期发病、年龄较大和视觉功能异常的特征。
结论
NEI-VFQ-25 可反映 FRDA 患者的视觉功能主观成分。
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