Pestalotiones A-D：植物内生真菌 的四个新次级代谢产物
Pestalotiones A-D: Four New Secondary Metabolites from the Plant Endophytic Fungus .
机构信息
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
University of Chinese Academy of Sciences, Beijing 100039, China.
出版信息
Molecules. 2020 Jan 22;25(3):470. doi: 10.3390/molecules25030470.
Two new xanthone derivatives, pestalotiones A () and B (), one new diphenyl ketone riboside, pestalotione C (), and one new diphenyl ether, pestalotione D (), along with five known compounds isosulochrin dehydrate (), 3,8-dihydroxy-6-methyl-9-oxo-9-xanthene-1-carboxylate (), isosulochrin (), chloroisosulochrin (), and pestalotether D (), were isolated from the crude extract of the plant endophytic fungus (N635). The structures of the new compounds were unambiguously deduced by HRESIMS and 1D/2D-NMR spectroscopic data. Compound showed modest cytotoxicity against the HeLa cell line with an IC value of 35.2 μM. Compound also showed cytotoxic to the HeLa and MCF-7 cell lines, with IC values of 60.8 and 22.6 μM, respectively. Additionally, compounds and exhibited antioxidant activity in scavenging DPPH radical with IC values of 54.2 and 59.2 μg/mL, respectively.
从植物内生真菌 （N635）的粗提物中分离得到了两个新的黄烷酮衍生物，即 pestalotiones A () 和 B (), 一个新的二苯甲酮核苷，pestalotione C (), 和一个新的二苯醚，pestalotione D (), 以及五个已知化合物，即脱水异硫代叶黄素 (), 3,8-二羟基-6-甲基-9-氧代-9-黄烷-1-羧酸酯 (), 异硫代叶黄素 (), 氯异硫代叶黄素 (), 和 pestalotether D ()。新化合物的结构通过 HRESIMS 和 1D/2D-NMR 光谱数据明确推断。化合物 对 HeLa 细胞系表现出适度的细胞毒性，IC 值为 35.2 μM。化合物 对 HeLa 和 MCF-7 细胞系也表现出细胞毒性，IC 值分别为 60.8 和 22.6 μM。此外，化合物 和 在清除 DPPH 自由基方面表现出抗氧化活性，IC 值分别为 54.2 和 59.2 μg/mL。
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