Aspelin P, Schmid-Schönbein H, Malotta H
Department of Diagnostic Radiology, Malmö General Hospital, University of Lund, Sweden.
Invest Radiol. 1988 Nov;23 Suppl 2:S326-33. doi: 10.1097/00004424-198811002-00004.
Red cell aggregate formation was studied both macroscopically and microscopically in blood mixed with a contrast medium, either ioxaglate or iohexol. Whole blood was layered on top of the contrast medium, and after being shaken, blood cells were separated from the medium by centrifugation. The kinetics of red cell aggregate formation were measured by a transparent rheoscope and a photoaggregometer at different shear rates. Coagulation studies were conducted on citrated platelet-rich plasma mixed with contrast media. Platelet shapes were observed with phase contrast optics, and coagulation times were measured. It was demonstrated that the increased red cell aggregation, which occurred during the initial contact between blood and the contrast medium, dispersed after being submitted to shear force and did not re-form in the remaining plasma. Since this phenomenon is associated with high concentrations of contrast media in nonflowing blood, the high shear rate in arteries and arterioles make it unimportant in the in vivo situation. Within highly concentrated contrast media solutions, blood clot formation was not inducible, and the risk of thrombus formation in fresh blood drawn into contrast medium-filled syringes appears minimal.
在与造影剂（碘克沙醇或碘海醇）混合的血液中，对红细胞聚集体的形成进行了宏观和微观研究。将全血置于造影剂之上，摇晃后，通过离心将血细胞与造影剂分离。在不同剪切速率下，使用透明流变仪和光聚集仪测量红细胞聚集体形成的动力学。对与造影剂混合的枸橼酸化富血小板血浆进行凝血研究。用相差光学显微镜观察血小板形态，并测量凝血时间。结果表明，血液与造影剂初始接触时出现的红细胞聚集增加，在受到剪切力后会消散，且不会在剩余血浆中重新形成。由于这种现象与非流动血液中高浓度造影剂有关，动脉和小动脉中的高剪切速率使其在体内情况下并不重要。在高浓度造影剂溶液中，无法诱导血液凝固，并且将新鲜血液抽入充满造影剂的注射器中形成血栓的风险似乎极小。
