人参补充剂对成年人血浆脂质浓度的功效：系统评价和荟萃分析。
The efficacy of ginseng supplementation on plasma lipid concentration in adults: A systematic review and meta-analysis.
机构信息
Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Student Research Committee, Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Complement Ther Med. 2020 Jan;48:102239. doi: 10.1016/j.ctim.2019.102239. Epub 2019 Nov 7.
OBJECTIVE
We performed a meta-analysis to evaluate the efficacy of ginseng supplementation on plasma lipid concentration.
METHODS
The search included PubMed, Scopus, ISI Web of Science, Cochrane library, and Google Scholar (up to April 2019) to identify randomized controlled trials (RCTs) investigating the effect of ginseng supplementation on serum lipid parameters. To estimate the overall summary effect, we used random-effects model.
RESULTS
Twenty-seven studies comprising 35 treatment arms comprising 1245 participants fulfilled the inclusion criteria. The meta-analysis results showed that consumption of ginseng did not significantly change the concentrations of total cholesterol (TC), triglyceride (TG), low density lipoprotein-cholesterol (LDL-C), and high density lipoprotein-cholesterol (HDL-C). However, subgroup analyses showed a significant lowering effect in high dose ginseng supplementation on TC, LDL-C and TG. Also, the impact of ginseng on TC and TG was significant in long-term interventions.
CONCLUSION
Further RCTs with longer supplementation durations in subjects with dyslipidemia are necessitated for a more robust assessment of the lipid-modulating properties of this plant.
目的
我们进行了荟萃分析，以评估人参补充剂对血浆脂质浓度的疗效。
方法
我们检索了 PubMed、Scopus、ISI Web of Science、Cochrane 图书馆和 Google Scholar（截至 2019 年 4 月），以确定人参补充剂对血清脂质参数影响的随机对照试验（RCT）。为了估计总体综合效应，我们使用了随机效应模型。
结果
27 项研究共包含 35 个治疗组，涉及 1245 名参与者，符合纳入标准。荟萃分析结果表明，人参的摄入并未显著改变总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）的浓度。然而，亚组分析显示，高剂量人参补充剂对 TC、LDL-C 和 TG 有显著的降低作用。此外，人参对 TC 和 TG 的影响在长期干预中是显著的。
结论
需要在血脂异常患者中进行更长时间补充人参的 RCT，以更有力地评估这种植物的调脂特性。
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