Centro de Biodiversidad y Descubrimiento de Drogas, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Panamá, Apartado 0843-01103, Panamá.
Smithsonian Tropical Research Institute, Balboa, Ancon, P. O. Box 0843-03092, Panama.
Mar Drugs. 2020 Jan 27;18(2):84. doi: 10.3390/md18020084.
Gorgonian octocorals are considered a prolific source of secondary metabolites with a wide range of biological activities, including anti-inflammatory activity. In particular, the genus is known for producing a wealth of diterpenes with complex chemical structures. The chemical study of the methanolic extract of collected in Bocas del Toro, on the Caribbean side of Panama, led to the isolation of three new eunicellin-type diterpenes: briarellin T (), asbestinin 27 (), asbestinin 28 () and the previously described asbestinin 17 (). The structures of the new compounds were determined by extensive NMR analyses and HRMS. Anti-inflammatory activity assays showed a significant reduction of the pro-inflammatory cytokines TNF-α, IL-6, IL-1β and IL-8 as well as a downregulation of COX-2 expression in LPS-stimulated THP-1 macrophages. These findings support the potential use of these marine compounds as therapeutic agents in the treatment of inflammatory diseases.
柳珊瑚被认为是次生代谢产物的丰富来源，具有广泛的生物活性，包括抗炎活性。特别是属以产生大量具有复杂化学结构的二萜类化合物而闻名。对在巴拿马加勒比一侧的博卡斯德尔托罗收集的柳珊瑚的甲醇提取物进行的化学研究导致了三种新的 eunicellin 型二萜类化合物的分离：briarellin T ()、asbestinin 27 ()、asbestinin 28 () 和之前描述的 asbestinin 17 ()。新化合物的结构通过广泛的 NMR 分析和 HRMS 确定。抗炎活性测定显示，这些海洋化合物可显著减少 LPS 刺激的 THP-1 巨噬细胞中促炎细胞因子 TNF-α、IL-6、IL-1β 和 IL-8 的产生，并下调 COX-2 的表达。这些发现支持这些海洋化合物作为治疗炎症性疾病的治疗剂的潜在用途。
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