Metabolic Syndrome Research Center, Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, 91179481564, Iran.
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Nutr J. 2020 Feb 3;19(1):11. doi: 10.1186/s12937-020-0526-3.
The purpose of this review was to investigate the effect of vitamin D supplements on hemoglobin concentration in subjects aged 17.5-68 years old; using randomized controlled trials (RCTs).
Relevant RCT studies were identified from January 2000 to January 2019 by using MeSH terms in PubMed, Embase, Cochrane Library, Clinical trials, Scopus databases and gray literature. The studies were reviewed systematically, and quality assessments were evaluated by the guidelines of the Cochrane risk of bias. The effect of vitamin D supplements (n = 14) on hemoglobin concentration was considered as primary outcome, while its effects on the levels of ferritin, transferrin saturation and iron status were derived as secondary outcomes. In total, 1385 subjects with age range of 17.5 to 68 years old were examined for 3 h to 6 months; Mean (standard deviation) or median interquartile changes in the hemoglobin concentration in each treatment group was recorded for meta-analysis.
Fourteen RCTs met the inclusion criteria. Current study findings propose that vitamin D supplementation leads to a non-significant reduction in hemoglobin levels in subjects (17.5-68 years old) [std. mean difference (SMD): 0.01; 95% CI: - 0.28, 0.29; P = 0.95], also it has no significant effect on ferritin concentrations [std. mean difference (SMD): -0.01; 95% CI: [- 0.20, 0.18; P = 0.91]. However, vitamin D supplementation demonstrated positive effects on transferrin saturation [mean difference (MD): 1.54; 95% CI: 0.31, 2.76; P = 0.01] and iron status [std. mean difference (SMD): 0.24; 95% CI: - 0.09, 0.39; P = 0.002].
Current review concluded that supplementation with vitamin D had no significant effect on hemoglobin and ferritin levels while positive effects on transferrin saturation and iron status were observed. Further clinical studies are required to determine the actual effect of this intervention on hemoglobin levels.
本综述旨在调查维生素 D 补充剂对 17.5-68 岁人群血红蛋白浓度的影响；使用随机对照试验 (RCT)。
通过使用 PubMed、Embase、Cochrane 图书馆、临床试验、Scopus 数据库和灰色文献中的 MeSH 术语，从 2000 年 1 月至 2019 年 1 月确定了相关的 RCT 研究。对研究进行了系统审查，并根据 Cochrane 偏倚风险指南评估了质量评估。将维生素 D 补充剂（n=14）对血红蛋白浓度的影响视为主要结局，而其对铁蛋白水平、转铁蛋白饱和度和铁状态的影响则作为次要结局。总共检查了 1385 名年龄在 17.5 至 68 岁之间的受试者，观察时间为 3 小时至 6 个月；记录每个治疗组血红蛋白浓度的平均（标准差）或中位数四分位距变化进行荟萃分析。
14 项 RCT 符合纳入标准。本研究结果表明，维生素 D 补充剂可导致受试者（17.5-68 岁）血红蛋白水平无显著降低[标准平均差（SMD）：0.01；95%CI：-0.28，0.29；P=0.95]，对铁蛋白浓度也无显著影响[标准平均差（SMD）：-0.01；95%CI：-0.20，0.18；P=0.91]。然而，维生素 D 补充剂对转铁蛋白饱和度[差值（MD）：1.54；95%CI：0.31，2.76；P=0.01]和铁状态[标准平均差（SMD）：0.24；95%CI：-0.09，0.39；P=0.002]有积极影响。
本综述得出结论，补充维生素 D 对血红蛋白和铁蛋白水平没有显著影响，而对转铁蛋白饱和度和铁状态有积极影响。需要进一步的临床研究来确定这种干预措施对血红蛋白水平的实际影响。
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