Graduate School, Wuhan Sports University, Wuhan, China.
School of Sports Art, Hunan University of Chinese Medicine, Changsha, China.
J Cell Physiol. 2020 Sep;235(9):5893-5902. doi: 10.1002/jcp.29588. Epub 2020 Feb 3.
Follistatin-like 1 (FSTL1) is a key factor in maintaining cardiac growth and development. It can be activated by exercise training and has a dual role in promoting cardiomyocyte proliferation and fibrosis, but its underlying mechanism is not fully understood. To elucidate the dual mechanism and target of FSTL1 regulating of cardiomyocyte proliferation and myocardial fibrosis, and the mechanism by which exercise-regulated FSTL1 improves cardiovascular disease, we explored the signal transduction pathway of FSTL1 promoting cardiomyocyte proliferation and fibrosis, and compared the effects of different modes of exercise on the dual role of FSTL1. We believe that the dual role of promoting cardiomyocyte proliferation and fibrosis may be related to the ratio of cardiomyocyte and myocardial interstitial cell proliferation, different stages of the disease, different degrees of fibrosis, immune repair process, and transforming growth factor-β activation. Compared with long-term excessive endurance exercise, moderate resistance exercise can activate cardiomyocyte proliferation pathway through FSTL1, which is one of the effective ways to prevent cardiovascular disease.
卵泡抑素样蛋白 1（Follistatin-like 1，FSTL1）是维持心脏生长和发育的关键因素。它可以被运动训练激活，在促进心肌细胞增殖和纤维化方面具有双重作用，但具体的作用机制尚不完全清楚。为了阐明 FSTL1 调节心肌细胞增殖和心肌纤维化的双重机制和靶点，以及运动调节 FSTL1 改善心血管疾病的机制，我们探讨了 FSTL1 促进心肌细胞增殖和纤维化的信号转导通路，并比较了不同运动方式对 FSTL1 双重作用的影响。我们认为，促进心肌细胞增殖和纤维化的双重作用可能与心肌细胞和心肌间质细胞增殖的比例、疾病的不同阶段、不同程度的纤维化、免疫修复过程和转化生长因子-β的激活有关。与长期过度的耐力运动相比，适度的抗阻运动可以通过 FSTL1 激活心肌细胞增殖途径，这是预防心血管疾病的有效途径之一。
