博桑因 A，一种从狭叶博桑中分离得到的新型 C-17-降乌苏烷型单萜吲哚生物碱。
Bousangine A, a novel C-17-nor aspidosperma-type monoterpenoid indole alkaloid from Bousigonia angustifolia.
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
出版信息
Fitoterapia. 2020 Apr;142:104491. doi: 10.1016/j.fitote.2020.104491. Epub 2020 Feb 4.
Two new monoterpenoid indole alkaloids, bousangines A (1) and B (2), were isolated from the twigs and leaves of Bousigonia angustifolia. Their structures including absolute configurations were elucidated by a combination of MS, NMR, ECD calculation, and single-crystal X-ray diffraction analysis. Bousangine A (1) possessed a rearrangement pentacyclic skeleton derived from aspidosperma-type alkaloids with C-17 degradation. Their antiproliferative activity against several human cancer cell lines were evaluated.
从狭叶坡绿萝的嫩枝和叶子中分离得到了两个新的单萜吲哚生物碱
bousangines A（1）和 B（2）。通过 MS、NMR、ECD 计算和单晶 X 射线衍射分析的组合，阐明了它们的结构包括绝对构型。Bousangine A（1）具有源自阿皮斯帕马型生物碱的重排五环骨架，并发生了 C-17 降解。评估了它们对几种人癌细胞系的抗增殖活性。
Zotero 插件