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2000 年至 2014 年滤泡性淋巴瘤的治疗模式:老年患者 SEER-Medicare 分析。

Follicular lymphoma treatment patterns between 2000 and 2014: a SEER-Medicare analysis of elderly patients.

机构信息

Department of Pharmaceutical Health Services Research, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.

Bayer Healthcare Pharmaceuticals, Inc., Whippany, NJ 07981, USA.

出版信息

Future Oncol. 2020 Mar;16(8):353-365. doi: 10.2217/fon-2019-0660. Epub 2020 Feb 11.

Abstract

Characterize follicular lymphoma (FL) treatment patterns among elderly patients using a dataset with longer follow-up time. Using the linked Surveillance, Epidemiology and End Results-Medicare data, we identified patients diagnosed with FL between 2000 and 2013 with claims data until 2014. We investigated the treatments received and assigned them to lines of treatment. We identified 10,238 elderly patients. Over a 4.7-year median follow-up, 78% of the patients received at least first-line treatment. Fewer individuals received second-line (47%) and third-line (30%) treatments. RCHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone), RCVP (rituximab, cyclophosphamide, vincristine and prednisolone) and rituximab monotherapy were the most common treatment regimens. One in five elderly patients did not receive FL-directed therapy. The most common treatment regimens were limited to RCHOP, RCVP and rituximab monotherapy.

摘要

利用具有更长随访时间的数据来描述老年滤泡性淋巴瘤(FL)患者的治疗模式。 使用链接的监测、流行病学和最终结果-医疗保险数据,我们确定了 2000 年至 2013 年间诊断为 FL 的患者,并在 2014 年之前使用索赔数据进行随访。我们调查了接受的治疗方法,并将其分配到治疗线。 我们确定了 10238 名老年患者。在 4.7 年的中位随访中,78%的患者接受了至少一线治疗。接受二线(47%)和三线(30%)治疗的患者较少。RCHOP(利妥昔单抗、环磷酰胺、多柔比星、长春新碱和泼尼松)、RCVP(利妥昔单抗、环磷酰胺、长春新碱和泼尼松)和利妥昔单抗单药治疗是最常见的治疗方案。 五分之一的老年患者未接受 FL 靶向治疗。最常见的治疗方案仅限于 RCHOP、RCVP 和利妥昔单抗单药治疗。

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