转录因子 E2F 在鼻咽癌的炎症和肿瘤发生中具有重要作用。
A significant role of transcription factors E2F in inflammation and tumorigenesis of nasopharyngeal carcinoma.
机构信息
Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, China; Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, China; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Changsha, China; Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Central South University, Changsha, China.
Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, China; Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, China; NHC Key Laboratory of Carcinogenesis (Central South University), Changsha, China.
出版信息
Biochem Biophys Res Commun. 2020 Apr 16;524(4):816-824. doi: 10.1016/j.bbrc.2020.01.158. Epub 2020 Feb 7.
Nasopharyngeal carcinoma (NPC) is a malignant tumor from head and neck with characteristics in remarkable geographic and racial distribution worldwide, which has the important features of vigorous proliferation and inflammatory cells infiltration. By analyzing the expression profile data of NPC, we found that the E2F-related gene sets were highly enriched in NPC tissues. E2F transcription factor family is an important cycle regulator, which can promote the malignant proliferation and tumorigenesis. Here, we showed that E2Fs accelerated malignant phenotypes of NPC cells. RNA sequencing revealed that E2Fs can significantly up-regulate the inflammatory pathways in NPC cells. E2F1, as a transcription factor, can active the transcription activity of IL-6 promoter, and modulate macrophage function through a microenvironment manner. Thus, this study characterized a significant role of E2Fs in inflammation and tumorigenesis of NPC, which provided a promising anti-tumor target in NPC, since E2Fs are highly expressed and activated in NPC.
鼻咽癌（NPC）是一种具有显著地理和种族分布特征的头颈部恶性肿瘤，其特征为增殖活跃和炎症细胞浸润。通过分析 NPC 的表达谱数据，我们发现 E2F 相关基因簇在 NPC 组织中高度富集。E2F 转录因子家族是一种重要的周期调节剂，可促进恶性增殖和肿瘤发生。在这里，我们表明 E2Fs 可加速 NPC 细胞的恶性表型。RNA 测序显示，E2Fs 可显著上调 NPC 细胞中的炎症通路。E2F1 作为一种转录因子，可激活 IL-6 启动子的转录活性，并通过微环境方式调节巨噬细胞功能。因此，这项研究表明 E2Fs 在 NPC 的炎症和肿瘤发生中具有重要作用，为 NPC 提供了一个有前途的抗肿瘤靶点，因为 E2Fs 在 NPC 中高度表达和激活。
Zotero 插件