近期感染 HCV 基因 1a 的男男性行为者中 NS5A 抑制剂耐药相关替换的传播。
Transmission of NS5A-Inhibitor Resistance-Associated Substitutions Among Men Who Have Sex With Men Recently Infected with Hepatitis C Virus Genotype 1a.
机构信息
Department of Viroscience, Erasmus Medical Center , University Medical Center, Rotterdam, The Netherlands.
Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, University Medical Center, Rotterdam, The Netherlands.
出版信息
Clin Infect Dis. 2020 Nov 5;71(8):e215-e217. doi: 10.1093/cid/ciaa145.
The transmission of direct-acting antiviral resistance-associated substitutions (RAS) could hamper hepatitis C virus (HCV) cure rates and elimination efforts. A phylogenetic analysis of 87 men who have sex with men recently infected with HCV genotype 1a placed one-third (28/87) in a large cluster, in which 96% harbored NS5A M28V RAS.
直接作用抗病毒耐药相关替换（RAS）的传播可能会降低丙型肝炎病毒（HCV）的治愈率和消除努力。对最近感染 HCV 基因 1a 型的 87 名男男性行为者进行的系统发育分析显示，三分之一（28/87）的人处于一个大的聚类中，其中 96%的人携带 NS5A M28V RAS。
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