临床孤立性快速眼动睡眠行为障碍患者的自主神经定量异常。

Quantitative sudomotor abnormalities in clinically isolated rapid eye movement sleep behavior disorder.

机构信息

Global Brain Health Institute, Department of Neurology & Neurological Sciences, University of California, San Francisco, San Francisco, CA, United States of America; Movement Disorders Unit, Department of Neurology, Tel Aviv Sourazky Medical Center, affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Israel.

Department of Neurology & Neurological Sciences, Stanford University, United States of America.

出版信息

Auton Neurosci. 2020 Mar;224:102645. doi: 10.1016/j.autneu.2020.102645. Epub 2020 Feb 1.

DOI:10.1016/j.autneu.2020.102645

PMID:32062418

Abstract

BACKGROUND

Post-ganglionic sudomotor abnormalities are common in Parkinson's disease (PD), however data in clinically isolated REM sleep behavior disorder (iRBD) are limited.

OBJECTIVE

To determine the prevalence of sudomotor abnormalities in a cohort of patients with iRBD.

METHODS

We performed a retrospective review of patients seen in our autonomic clinic who underwent testing with the quantitative sudomotor axon reflex test (QSART). We identified three groups for comparison: 1.) iRBD, 2.) PD with RBD (PDwRBD) 3.) PD without RBD (PDwoRBD).

RESULTS

PDwRBD (n = 27) patients demonstrated the greatest sudomotor abnormalities (sudomotor CASS 1.44 ± 1.24), followed by PDwoRBD (n = 23, 0.57 ± 0.5) and iRBD (n = 20, 0.55 ± 0.94) (p = 0.015). Twenty percent of patients with iRBD had an abnormal result, compared to 67% PDwRBD and 35% PDwoRBD.

DISCUSSION

Sudomotor abnormalities are common in patients with iRBD, supporting the concept that peripheral autonomic impairment occurs early in the course of disease.

摘要

背景

节后自主神经功能障碍在帕金森病（PD）中很常见，但在临床孤立性 REM 睡眠行为障碍（iRBD）中的数据有限。

目的

确定自主神经诊所中一组 iRBD 患者自主神经功能障碍的患病率。

方法

我们对在我们的自主神经诊所就诊并接受定量自主神经轴反射测试（QSART）测试的患者进行了回顾性研究。我们确定了三组进行比较：1）iRBD，2）有 RBD 的 PD（PDwRBD），3）无 RBD 的 PD（PDwoRBD）。

结果

PDwRBD（n=27）患者表现出最大的自主神经功能障碍（自主神经 CASS 1.44±1.24），其次是 PDwoRBD（n=23，0.57±0.5）和 iRBD（n=20，0.55±0.94）（p=0.015）。20%的 iRBD 患者出现异常结果，而 PDwRBD 为 67%，PDwoRBD 为 35%。