儿童疑似传染病合并中重度中性粒细胞减少的管理。
The Management of Young Children With a Likely Infectious Condition Presenting Moderate to Severe Neutropenia.
机构信息
Department of Pediatrics.
Clinical and Evaluative Research Platform, Research Center, CHU de Québec-Université Laval.
出版信息
J Pediatr Hematol Oncol. 2020 Nov;42(8):e778-e782. doi: 10.1097/MPH.0000000000001749.
OBJECTIVE
The objective of this study was to describe the outcome of healthy children presenting with newly-diagnosed neutropenia in an infectious context.
RESULTS
A total of 184 episodes of neutropenia were included in children 3 months to 5 years of age. There were 118 (64%) episodes of moderate neutropenia and 66 (36%) of severe neutropenia (SN). SN episodes were more likely related to intensification of antibiotic regimen used and further investigations. The median duration of neutropenia was 8.5 days. Chronic benign neutropenia occurred in 7 (4%) patients.
CONCLUSION
SN led to intensification of antibiotic therapy, but no children encountered an unfavorable outcome and the neutropenia episodes were short-lived.
目的
本研究旨在描述在感染背景下新诊断为中性粒细胞减少症的健康儿童的结局。
结果
共纳入 184 例年龄在 3 个月至 5 岁的儿童中性粒细胞减少症发作。其中 118 例（64%）为中度中性粒细胞减少症，66 例（36%）为严重中性粒细胞减少症（SN）。SN 发作更可能与抗生素方案的强化使用和进一步的检查有关。中性粒细胞减少症的中位持续时间为 8.5 天。7 例（4%）患者发生慢性良性中性粒细胞减少症。
结论
SN 导致抗生素治疗的强化，但没有儿童出现不良结局，且中性粒细胞减少症发作时间短。
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