一例伴有醛固酮分泌性腺瘤的糖皮质激素可抑制性醛固酮增多症。

A case of glucocorticoid-suppressible hyperaldosteronism with aldosterone producing adenoma.

作者信息

Kato S, Haji M, Yanase T, Nawata H, Kato K, Ibayashi H

机构信息

Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

出版信息

Endocrinol Jpn. 1988 Apr;35(2):311-20. doi: 10.1507/endocrj1954.35.311.

DOI:10.1507/endocrj1954.35.311

PMID:3208706

Abstract

A 34-yr-old woman with hypertension (142/102 mmHg), hypokalemia, high plasma and urinary aldosterone and low plasma renin activity was studied. A left adrenal tumor and enlarged right adrenal gland were demonstrated by adrenal venography. During administration of dexamethasone (2 mg daily, for 3 weeks), urinary aldosterone excretion decreased abruptly from 22.5 to 9-11 micrograms/day, serum potassium increased and blood pressure fell to 120-130/80-90 mmHg. After left adrenalectomy, all manifestations improved with no medication. The resected adrenal gland revealed clear cell adenoma and micronodular adrenocortical hyperplasia. The patient was considered to be a rare case of glucocorticoid-suppressible hyperaldosteronism with an aldosterone-producing adenoma.

摘要

对一名34岁患有高血压（142/102 mmHg）、低钾血症、血浆和尿醛固酮水平升高且血浆肾素活性降低的女性进行了研究。肾上腺静脉造影显示左侧肾上腺有肿瘤，右侧肾上腺增大。在给予地塞米松（每日2 mg，共3周）期间，尿醛固酮排泄量从每日22.5微克突然降至9 - 11微克，血清钾升高，血压降至120 - 130/80 - 90 mmHg。左肾上腺切除术后，所有症状在未用药的情况下均有所改善。切除的肾上腺显示为透明细胞腺瘤和微结节性肾上腺皮质增生。该患者被认为是一例罕见的糖皮质激素可抑制性醛固酮增多症合并醛固酮分泌腺瘤。