Unit of Clinical Alcohol Research, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.
OPEN, Odense Patient Data Explorative Network, Odense University Hospital, Odense, Denmark.
Subst Use Misuse. 2020;55(8):1214-1222. doi: 10.1080/10826084.2020.1731546. Epub 2020 Feb 28.
: Understanding the variation of alcohol use disorder (AUD) among a clinical sample of patients aged 60 and older, by identifying latent classes of AUD and exploring risk factors and outcomes of treatment associated with the class. : We used the Danish subsample ( = 341) from the Elderly Study. Latent class analysis was used to identify classes based on the 11 symptoms of DSM-5 AUD. We analyzed the associations between class membership and sociodemographic variables, alcohol consumption, and drinking-related outcome of treatment. : Three latent classes were identified. Individuals in the low-symptomatic class (34.85%) displayed low endorsement of DSM-5 criteria "Withdrawal", "Time Spent", "Less activities" compared to the other classes, and had fewest drinks per drinking day. Individuals in the moderate-symptomatic class (32.69%) were most likely to be intoxicated in hazardous situations, and those in the high-symptomatic class (32.47%) displayed, with a few exceptions, the highest probabilities of all DSM-5 criteria. Female gender, living alone and prior AUD treatment was associated with increased risk of being in the high-symptomatic class. No difference between classes was found with respect to years with AUD and frequency of drinking days, and latent class membership had no effect on drinking outcome after treatment, when controlling for baseline. : Three classes of DSM-5 AUD among older adults in treatment emerged, displaying a low-moderate-high distribution, advocating for a unidimensional construct of DSM-5 AUD. Although different with respect to baseline risk factors, no strong connection between DSM-5 latent class and alcohol consumption after AUD treatment was found.HighlightsAmong 341 older alcohol use disorder (AUD) outpatients, three latent classes of DSM-5 AUD emerged.The classes of DSM-5 AUD displayed a low-moderate-high endorsement of DSM-5 AUD characteristics.The three classes had similar alcohol-related treatment outcomes.
了解 60 岁及以上临床患者群体中酒精使用障碍(AUD)的变化,通过确定 AUD 的潜在类别,并探索与类别相关的治疗风险因素和结果。
我们使用丹麦老年人研究的子样本(n=341)。基于 DSM-5 AUD 的 11 个症状,采用潜在类别分析确定类别。我们分析了类别成员与社会人口学变量、饮酒量和与治疗相关的饮酒结果之间的关联。
确定了三个潜在类别。低症状类别(34.85%)的个体与其他类别相比,DSM-5 标准“戒断”、“时间花费”、“活动减少”的症状较少,每天饮酒量也较少。中等症状类别(32.69%)的个体最有可能在危险情况下醉酒,而高症状类别(32.47%)的个体除了少数例外,所有 DSM-5 标准的可能性最高。女性、独居和既往 AUD 治疗与高症状类别的风险增加相关。在控制基线后,各类别之间在 AUD 持续时间和饮酒天数频率方面没有差异,且潜在类别成员对治疗后的饮酒结果没有影响。
治疗中老年成年人的 DSM-5 AUD 出现了三个类别,呈现出低-中-高分布,提倡 DSM-5 AUD 的单维结构。尽管在基线风险因素方面存在差异,但在 AUD 治疗后,DSM-5 潜在类别与饮酒之间没有很强的联系。
在 341 名年龄较大的酒精使用障碍(AUD)门诊患者中,出现了三个潜在的 DSM-5 AUD 类别。
DSM-5 AUD 类别显示出 DSM-5 AUD 特征的低-中-高认可程度。
这三个类别具有相似的与酒精相关的治疗结果。