克隆诺克普根 A、B 和 C，来自冲绳真菌紧密枝孢菌 FKR-0021 的新型抗疟原虫共代谢产物。
Clonocoprogens A, B and C, new antimalarial coprogens from the Okinawan fungus Clonostachys compactiuscula FKR-0021.
机构信息
Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
出版信息
J Antibiot (Tokyo). 2020 Jun;73(6):365-371. doi: 10.1038/s41429-020-0292-7. Epub 2020 Mar 6.
Three new antimalarial compounds, clonocoprogens A, B, and C, were isolated from the static culture of an Okinawan fungus, Clonostachys compactiuscula FKR-0021. These compounds were new analogs of N-palmitoylcoprogen, reported as a siderophore. They showed moderate antimalarial activity against chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum strains, with IC values ranging from 1.7 to 9.9 µM.
从冲绳真菌 Clonostachys compactiuscula FKR-0021 的静态培养物中分离得到三种新的抗疟化合物，分别为 clonocoprogens A、B 和 C。这些化合物是 N-棕榈酰 coprogen 的新型类似物，报道为一种铁载体。它们对氯喹敏感和氯喹耐药的恶性疟原虫株表现出中等的抗疟活性，IC 值范围为 1.7 至 9.9µM。
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