Sakai Kenji, Ohashi Tomofumi, Shimura Yuhi, Teranishi Reyugo, Hara Shuichiro, Takayama Keita, Yoshida Masayuki, Yoneda Kazuhiro, Osawa Hideki, Ide Yoshihito, Noro Hiroshi, Hirao Takafumi, Iwasaki Teruo, Hatanaka Nobutaka, Yamasaki Yoshio
Dept. of Surgery, Japan Community Health care Organization(JCHO)Osaka Hospital.
Gan To Kagaku Ryoho. 2019 Dec;46(13):2306-2308.
A 69-year-old man underwent a Miles operation with D3 lymph node dissection for rectal cancer. The pathological diagnosis was adenocarcinoma(Rb, A, ly2, v3, N2M0P0H0, Stage Ⅲb). Adjuvant chemotherapy was added for 6 months after the rectal resection. Metastasis in the left lung was detected 1 year and 10 months after rectal resection for which large segmental resection was performed. Without the onset of any new lesions, the patient underwent subsequent follow-up examinations. Abdominal CT performed for increased tumor marker levels observed at 6 years and 8 months after rectal resection revealed a mass suggestive of pancreatic ductal adenocarcinoma for which distal pancreatectomy was performed. The pathological diagnosis was metastasis to the pancreas from the rectal cancer as the tumor cells were immunohistochemically negative for cytokeratin 7 and positive for cytokeratin 20. There has been no indication of recurrence for 13 months after the pancreatic surgery. Resectable pancreatic metastasis from colorectal cancer is rarely reported. However, pancreatic resection may result in long-term survival in some cases. Patients that tolerate pancreatectomy and have no metastasis in the other organs should be considered good candidates for pancreatic resection. We present this case with a review of the literature.
一名69岁男性因直肠癌接受了腹会阴联合切除术及D3淋巴结清扫术。病理诊断为腺癌(Rb,A,ly2,v3,N2M0P0H0,Ⅲb期)。直肠切除术后追加辅助化疗6个月。直肠切除术后1年10个月发现左肺转移,遂行大片段切除术。在未出现任何新病灶的情况下,患者接受了后续随访检查。直肠切除术后6年8个月因肿瘤标志物水平升高行腹部CT检查,发现一个提示胰腺导管腺癌的肿块,遂行胰远端切除术。病理诊断为直肠癌胰腺转移,因为肿瘤细胞免疫组化细胞角蛋白7阴性、细胞角蛋白20阳性。胰腺手术后13个月无复发迹象。结直肠癌可切除性胰腺转移的报道很少。然而,在某些情况下,胰腺切除可能会带来长期生存。耐受胰腺切除术且其他器官无转移的患者应被视为胰腺切除的良好候选者。我们报告此病例并复习文献。