Kittleson M, Keene B, Pion P, Woodfield J
Department of Medicine, School of Veterinary Medicine, University of California, Davis 95616.
J Am Vet Med Assoc. 1988 Dec 15;193(12):1525-9.
Verapamil, a calcium channel-blocking drug, was administered IV at a dosage that ranged from 0.05 to 0.15 mg/kg of body weight to 14 dogs with supraventricular tachycardia. The dosage was titrated, administering 0.05 mg/kg every 5 to 30 minutes following the initial 0.05 mg/kg dose in all but 1 dog. The drug terminated the arrhythmia in 12 dogs and slowed the ventricular rate in 1 dog. One dog was unresponsive to verapamil administration and became transiently hypotensive after the administration of a total dose of 0.15 mg/kg over 5 to 6 minutes. Various arrhythmias occurred after verapamil administration, but none required additional treatment or caused serious sequelae. Verapamil was an effective treatment for acutely converting supraventricular tachycardia to sinus rhythm in these dogs. It appears to be safe when administered in the aforementioned dosage range.
维拉帕米是一种钙通道阻滞剂，以0.05至0.15毫克/千克体重的剂量静脉注射给14只患有室上性心动过速的狗。剂量是滴定的，除1只狗外，在初始剂量0.05毫克/千克后，每5至30分钟给予0.05毫克/千克。该药物使12只狗的心律失常终止，使1只狗的心室率减慢。1只狗对维拉帕米给药无反应，在5至6分钟内给予总剂量0.15毫克/千克后出现短暂性低血压。维拉帕米给药后出现了各种心律失常，但均无需额外治疗或导致严重后遗症。维拉帕米是将这些狗的急性室上性心动过速转为窦性心律的有效治疗方法。在上述剂量范围内给药时似乎是安全的。
