载脂蛋白 A1 与单核细胞/高密度脂蛋白胆固醇比值和非高密度脂蛋白胆固醇与冠心病的关系。
Relationship between non-high-density lipoprotein cholesterol/apolipoprotein A-I and monocyte/high-density lipoprotein cholesterol ratio and coronary heart disease.
机构信息
From the Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, China.
出版信息
Coron Artery Dis. 2020 Nov;31(7):623-627. doi: 10.1097/MCA.0000000000000881.
OBJECTIVE
To investigate the association between non-high-density lipoprotein cholesterol/apolipoprotein A-I and monocyte/high-density lipoprotein cholesterol ratio and degree of coronary artery stenosis proven by coronary angiography.
METHODS
A total of 1867 patients were enrolled into this study and analyzed retrospectively. Three hundred eighty-five non-coronary artery disease hospitalized patients were selected as control group, 1482 patients diagnosed as coronary artery disease were classified into three subgroups according to the tertiles of their SYNTAX score. We compared the level of non-high-density lipoprotein cholesterol/apolipoprotein A-I and monocyte/high-density lipoprotein cholesterol ratio among the three subgroups. The Spearman correlation was used to analyze the correlation between non-high-density lipoprotein cholesterol/apolipoprotein A-I and monocyte/high-density lipoprotein cholesterol ratio and SYNTAX, logistic regression was used for analyzing independent predictors of coronary artery disease.
RESULTS
The level of non-high-density lipoprotein cholesterol/apolipoprotein A-I and monocyte/high-density lipoprotein cholesterol ratio was higher in coronary artery disease group compared with non-coronary artery disease group (P < 0.01). The Spearman correlation analysis showed that non-high-density lipoprotein cholesterol/apolipoprotein A-I and monocyte/high-density lipoprotein cholesterol ratio were significantly correlated with SYNTAX score (r = 0.081, P < 0.001; r = 0.216, P < 0.001). In multivariate logistic regression analysis showed that non-high-density lipoprotein cholesterol/apolipoprotein A-I and monocyte/high-density lipoprotein cholesterol ratio were independent predictors of coronary artery disease (odds ratio = 3.645, 95% confidence interval, 1.267-10.486; OR = 2.096, 95% confidence interval, 1.438-3.054).
CONCLUSION
Non-high-density lipoprotein cholesterol/apolipoprotein A-I and monocyte/high-density lipoprotein cholesterol ratio were associated with the severity of coronary artery lesions, which can be used as a biomarker for the evaluation of severity of coronary artery disease.
目的
探讨非高密度脂蛋白胆固醇/载脂蛋白 A-I 与单核细胞/高密度脂蛋白胆固醇比值与冠状动脉造影证实的冠状动脉狭窄程度的关系。
方法
本研究共纳入 1867 例患者，进行回顾性分析。选取 385 例非冠状动脉疾病住院患者作为对照组，将 1482 例诊断为冠心病的患者根据 SYNTAX 评分的三分位数分为三组。比较三组之间非高密度脂蛋白胆固醇/载脂蛋白 A-I 与单核细胞/高密度脂蛋白胆固醇比值的水平。采用 Spearman 相关分析非高密度脂蛋白胆固醇/载脂蛋白 A-I 与单核细胞/高密度脂蛋白胆固醇比值与 SYNTAX 的相关性，采用 logistic 回归分析冠心病的独立预测因素。
结果
冠心病组的非高密度脂蛋白胆固醇/载脂蛋白 A-I 与单核细胞/高密度脂蛋白胆固醇比值水平高于非冠状动脉疾病组（P < 0.01）。Spearman 相关分析显示，非高密度脂蛋白胆固醇/载脂蛋白 A-I 与单核细胞/高密度脂蛋白胆固醇比值与 SYNTAX 评分呈显著正相关（r = 0.081，P < 0.001；r = 0.216，P < 0.001）。多变量 logistic 回归分析显示，非高密度脂蛋白胆固醇/载脂蛋白 A-I 与单核细胞/高密度脂蛋白胆固醇比值是冠心病的独立预测因素（比值比=3.645，95%置信区间，1.267-10.486；OR=2.096，95%置信区间，1.438-3.054）。
结论
非高密度脂蛋白胆固醇/载脂蛋白 A-I 与单核细胞/高密度脂蛋白胆固醇比值与冠状动脉病变严重程度相关，可作为评估冠状动脉疾病严重程度的生物标志物。
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