Department of Medical Genetics, University of Antwerp, Antwerp, Belgium.
Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Obes Rev. 2020 Jul;21(7):e13019. doi: 10.1111/obr.13019. Epub 2020 Mar 14.
Obesity is a highly heritable multifactorial disease that places an enormous burden on human health. Its increasing prevalence and the concomitant-reduced life expectancy has intensified the search for new analytical methods that can reduce the knowledge gap between genetic susceptibility and functional consequences of the disease pathology. Although the influence of genetics and epigenetics has been studied independently in the past, there is increasing evidence that genetic variants interact with environmental factors through epigenetic regulation. This suggests that a combined analysis of genetic and epigenetic variation may be more effective in characterizing the obesity phenotype. To date, limited genome-wide integrative analyses have been performed. In this review, we provide an overview of the latest findings, advantages, and challenges and discuss future perspectives.
肥胖是一种高度遗传性的多因素疾病，给人类健康带来了巨大的负担。其发病率的不断增加和随之而来的预期寿命的缩短，加剧了人们对新的分析方法的需求，这种方法可以缩小遗传易感性与疾病病理的功能后果之间的知识差距。尽管过去已经独立研究了遗传学和表观遗传学的影响，但越来越多的证据表明，遗传变异通过表观遗传调控与环境因素相互作用。这表明，对遗传和表观遗传变异的综合分析可能更有效地描述肥胖表型。迄今为止，已经进行了有限的全基因组综合分析。在这篇综述中，我们提供了最新发现、优势和挑战的概述，并讨论了未来的展望。
