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从 L.中分离得到的两种新酰胺生物碱及其乙酰胆碱酯酶抑制活性。

Two new amide alkaloids from L. and their anticholinesterase activities.

机构信息

School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China.

School of The First Clinic, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, P.R. China.

出版信息

Nat Prod Res. 2021 Nov;35(21):3794-3800. doi: 10.1080/14786419.2020.1739040. Epub 2020 Mar 20.

Abstract

Two new amide alkaloids, identified as 5,6-dihydroxy-3,4-dihydroisoquinolin-1(2H)-one, named oleraciamide G () and (E)-1-(5-hydroxy-6-((3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1H-indol-1-yl)-3-(4-hydroxyphenyl)prop-2-en-1-one, named oleraindole D () were obtained from L. Their structures were determined by spectroscopic methods, including the 1 D and 2 D NMR, high-resolution electrospray ionization time-of-flight mass spectrometry. In addition, compounds and presented anticholinesterase activities with IC values of 65.71 ± 0.15 μM and 58.78 ± 0.36 μM, respectively.

摘要

从 L.中分离得到两个新的酰胺生物碱,分别鉴定为 5,6-二羟基-3,4-二氢异喹啉-1(2H)-酮(命名为奥勒拉酰胺 G ())和(E)-1-(5-羟基-6-((3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)-1H-吲哚-1-基)-3-(4-羟基苯基)-2-丙烯-1-酮,命名为奥勒拉因 D ()。它们的结构通过光谱方法确定,包括 1D 和 2D NMR、高分辨率电喷雾电离飞行时间质谱。此外,化合物 和 表现出乙酰胆碱酯酶抑制活性,IC 值分别为 65.71±0.15 μM 和 58.78±0.36 μM。

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