Zhang Hongyu, Liang Ka, Ke Liuhua, Tang Shifu
Department of Clinical Laboratory, The Third Affiliated Hospital of Guangxi University of Chinese Medicine, Liuzhou Traditional Chinese Medical Hospital, The Third Clinical Faculty of Guangxi University of Chinese Medicine, Liuzhou, China.
J Clin Lab Anal. 2020 Aug;34(8):e23309. doi: 10.1002/jcla.23309. Epub 2020 Mar 20.
Red cell distribution width (RDW) and mean platelet volume (MPV) are considered to be associated with tumors. We investigated the diagnostic value of RDW, MPV, and cancer antigen 125 (CA125), alone or in combination, in the diagnosis of endometrial cancer and endometrial hyperplasia.
This study included 144 patients with endometrial cancer (stage I: 32; II: 42; III: 48; and IV: 22), 104 patients with endometrial hyperplasia, and 80 healthy control subjects. The whole blood cell parameters were analyzed by a Mindray Blood Cell Analyzer (CAL8000), whereas CA125 was analyzed using an Architect i2000 Analyzer (Abbott).
Significant differences in RDW, MPV, and CA125 level were observed in the endometrial cancer, endometrial hyperplasia, and control groups (P < .05). Red cell distribution width was positively correlated (r = .735) whereas MPV was negatively correlated with (r = -.736) endometrial cancer staging. The area under the receiver operating characteristic curve of the combined diagnosis of endometrial cancer based on RDW, MPV, and CA125 was 0.924 (95% CI: 0.881-0.955). The sensitivity and specificity of the combined diagnosis were larger than those of the independent detections involving RDW, MPV, and CA125.
The combination of RDW, MPV, and CA125 can improve the differential diagnosis of endometrial cancer and endometrial hyperplasia.
红细胞分布宽度（RDW）和平均血小板体积（MPV）被认为与肿瘤有关。我们研究了RDW、MPV和癌抗原125（CA125）单独或联合应用在子宫内膜癌和子宫内膜增生诊断中的价值。
本研究纳入144例子宫内膜癌患者（Ⅰ期：32例；Ⅱ期：42例；Ⅲ期：48例；Ⅳ期：22例）、104例子宫内膜增生患者和80例健康对照者。采用迈瑞血细胞分析仪（CAL8000）分析全血细胞参数，采用雅培i2000分析仪分析CA125。
子宫内膜癌组、子宫内膜增生组和对照组的RDW、MPV和CA125水平存在显著差异（P <.05）。红细胞分布宽度与子宫内膜癌分期呈正相关（r = 0.735），而MPV与子宫内膜癌分期呈负相关（r = -0.736）。基于RDW、MPV和CA125联合诊断子宫内膜癌的受试者工作特征曲线下面积为0.924（95%CI：0.881 - 0.955）。联合诊断的敏感性和特异性高于涉及RDW、MPV和CA125的独立检测。
RDW、MPV和CA125联合应用可提高子宫内膜癌和子宫内膜增生的鉴别诊断能力。
