系统性红斑狼疮合并多种自身免疫性疾病伴广泛外周坏疽。
Systemic Lupus Erythematosus with Multiple Autoimmune Disease Presented with Extensive Peripheral Gangrene.
作者信息
Alzughayyar Tareq Z, Zalloum Jihad Samer, Elqadi Mohammad N, Abukhalaf Sadi A, Abunejma Fawzy M, Alkhanafsa Mohammed M Y, Haif Motasem H M, Alqarajeh Firas, Mesk Mo'min R, Misk Rami A
机构信息
Al-Quds University, Faculty of Medicine, Jerusalem, State of Palestine.
Pediatric Rheumatologist, Al-Ahli Hospital, Hebron, State of Palestine.
出版信息
Case Rep Rheumatol. 2020 Mar 10;2020:8278275. doi: 10.1155/2020/8278275. eCollection 2020.
Systemic lupus erythematosus (SLE) is an autoimmune disease and can be associated with other autoimmune diseases. SLE usually presents with skin change and rarely presents with gangrene. SLE gangrene usually involves the digits of upper extremities. We report the first case of SLE associated with an extremely rare constellation of neuromyelitis Optica (NMO) and diabetes mellitus type 1, presented with a rare form of the SLE gangrene which involves bilateral lower extremities up to midlegs, a case that has not yet been reported in the literature. Although SLE gangrene may respond to immunosuppressants, it has a high risk of complications that can end up with amputations.
系统性红斑狼疮（SLE）是一种自身免疫性疾病，可与其他自身免疫性疾病相关。SLE通常表现为皮肤改变，很少表现为坏疽。SLE坏疽通常累及上肢手指。我们报告了首例SLE合并极罕见的视神经脊髓炎谱系疾病（NMO）和1型糖尿病，表现为一种罕见的SLE坏疽形式，累及双侧下肢直至小腿中部，这一病例尚未见文献报道。尽管SLE坏疽可能对免疫抑制剂有反应，但它有很高的并发症风险，最终可能导致截肢。
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