University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, F-59000 Lille, France.
University of Lille, CNRS UMR9017, Inserm U1019, CHRU Lille, Institut Pasteur de Lille, CIIL - Center for Infection and Immunity of Lille, 59000 Lille, France.
Nutrients. 2020 Mar 20;12(3):827. doi: 10.3390/nu12030827.
Unhealthy lifestyle choices, such as bad eating behaviors and cigarette smoking, have major detrimental impacts on health. However, the inter-relations between obesity and smoking are still not fully understood. We thus developed an experimental model of high-fat diet-fed obese C57BL/6 male mice chronically exposed to cigarette smoke. Our study evaluated for the first time the resulting effects of the combined exposure to unhealthy diet and cigarette smoke on several metabolic, pulmonary, intestinal, and cardiac parameters. We showed that the chronic exposure to cigarette smoke modified the pattern of body fat distribution in favor of the visceral depots in obese mice, impaired the respiratory function, triggered pulmonary inflammation and emphysema, and was associated with gut microbiota dysbiosis, cardiac hypertrophy and myocardial fibrosis.
不健康的生活方式选择,如不良的饮食习惯和吸烟,对健康有重大的不利影响。然而,肥胖和吸烟之间的相互关系仍不完全清楚。因此,我们建立了一种慢性暴露于香烟烟雾的高脂肪饮食喂养肥胖 C57BL/6 雄性小鼠的实验模型。我们的研究首次评估了不健康饮食和香烟烟雾联合暴露对多种代谢、肺、肠道和心脏参数的影响。我们发现,香烟烟雾的慢性暴露改变了肥胖小鼠体脂肪分布的模式,有利于内脏脂肪的积累,损害了呼吸功能,引发了肺部炎症和肺气肿,并与肠道微生物失调、心脏肥大和心肌纤维化有关。