生育力保存的新前沿：关于高促性腺激素性性腺功能减退男性生育力优化的假说
New frontiers in fertility preservation: a hypothesis on fertility optimization in men with hypergonadotrophic hypogonadism.
作者信息
Herati Amin S, Kohn Taylor P, Kassiri Borna
机构信息
Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
出版信息
Transl Androl Urol. 2020 Mar;9(Suppl 2):S171-S177. doi: 10.21037/tau.2019.12.39.
Strategies exist that can mitigate the risk of causing iatrogenic infertility when men require testosterone replacement therapy (TRT). This article reviews the current medical therapies that preserve spermatogenesis when TRT is indicated. Furthermore, we highlight the re-emerging concept of hypothalamic-pituitary-gonadal (HPG) axis reset in hypergonadotrophic, hypogonadal infertile men who are planning sperm retrieval procedures. Finally, we present our hypothesis for a novel protocol to optimize hypergonadotrophic hypogonadal men before sperm extraction surgeries hormonally.
当男性需要睾酮替代疗法（TRT）时，存在一些策略可以降低医源性不育的风险。本文回顾了在需要进行TRT时可保留精子发生的当前医学疗法。此外，我们强调了在计划进行取精手术的高促性腺激素性性腺功能减退不育男性中，下丘脑-垂体-性腺（HPG）轴重置这一重新出现的概念。最后，我们提出了一个新方案的假设，即在精子提取手术前通过激素优化高促性腺激素性性腺功能减退男性的状况。
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