先天免疫和炎症信号中的高级组装：细胞生物学中的一般原则。
Higher-order assemblies in innate immune and inflammatory signaling: A general principle in cell biology.
机构信息
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, and Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA; School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150001, China.
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, and Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
出版信息
Curr Opin Cell Biol. 2020 Apr;63:194-203. doi: 10.1016/j.ceb.2020.03.002. Epub 2020 Apr 6.
Abstract
Higher-order supramolecular complexes-dubbed signalosomes carry out key signaling and effector functions in innate immunity and inflammation. In this review, we present several recently discovered signalosomes that are formed either by stable protein-protein interactions or by dynamic liquid-liquid phase separation. Structural features of these signalosomes are highlighted to elucidate their functions and biological insights.
摘要
高等阶超分子复合物——信号小体，在先天免疫和炎症中执行关键的信号转导和效应功能。在这篇综述中，我们介绍了几种最近发现的信号小体，它们要么是通过稳定的蛋白质-蛋白质相互作用形成的，要么是通过动态的液-液相分离形成的。强调了这些信号小体的结构特征，以阐明它们的功能和生物学见解。
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