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一种用于慢性胰腺炎评估和随访的新超声评分:“Gemelli USCP 评分”。

A new ultrasound score for the assessment and follow-up of chronic pancreatitis: The 'Gemelli USCP score'.

机构信息

Division of Internal Medicine and Gastroenterology, Fondazione Policlinico Universitario A. Gemelli IRCCS - Catholic University of the Sacred Heart, Rome, Italy; Pancreatic Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS - Catholic University of the Sacred Heart, Rome, Italy.

Division of Internal Medicine and Gastroenterology, Fondazione Policlinico Universitario A. Gemelli IRCCS - Catholic University of the Sacred Heart, Rome, Italy.

出版信息

Dig Liver Dis. 2020 Jun;52(6):644-650. doi: 10.1016/j.dld.2020.03.003. Epub 2020 Apr 6.

Abstract

BACKGROUND

Ultrasound (US) is frequently the first line imaging technique used in patients with abdominal pain and clinical suspicion of chronic pancreatitis (CP), but its role in the diagnosis and follow-up of CP is still controversial.

AIMS

We aimed to develop a dedicated score for the US staging of CP and to evaluate the agreement of this score with standard imaging techniques.

METHODS

Ninety consecutive patients with a diagnosis of CP referred to the pancreatic outpatient clinic of A. Gemelli Hospital between June and September 2018 were recruited in the study. Patients underwent pancreatic US to evaluate different morphological parameters to develop an US based score system, called the Gemelli UltraSound Chronic Pancreatitis (USCP) score.

RESULTS

The Gemelli USCP score significantly increased according to the Cambridge score for both mean value (p<0.0001) and each parameter evaluated (p<0.0001). Moreover, we found a significant correlation between the score and laboratory parameters related to pancreatic exocrine insufficiency such as vitamin D, B9, and B12 deficiency and fecal elastase values (p<0.0001).

CONCLUSIONS

The development of a dedicated US score could be useful in the follow up of patients with CP as alternative non-invasive technique to standard radiological imaging.

摘要

背景

超声(US)是腹部疼痛且临床疑似慢性胰腺炎(CP)患者常用的一线影像学检查方法,但在 CP 的诊断和随访中的作用仍存在争议。

目的

我们旨在开发一种专门用于 CP 超声分期的评分,并评估该评分与标准影像学技术的一致性。

方法

2018 年 6 月至 9 月期间,连续招募了 90 例在 A. Gemelli 医院胰腺门诊就诊的 CP 患者参与本研究。对患者进行胰腺超声检查,以评估不同的形态参数,从而开发一种基于超声的评分系统,称为 Gemelli UltraSound Chronic Pancreatitis(USCP)评分。

结果

Gemelli USCP 评分随着剑桥评分的增加而显著升高,无论是平均值(p<0.0001)还是每个评估参数(p<0.0001)均如此。此外,我们发现评分与维生素 D、B9 和 B12 缺乏以及粪便弹性蛋白酶值等与胰腺外分泌功能不全相关的实验室参数之间存在显著相关性(p<0.0001)。

结论

开发专门的超声评分可能有助于 CP 患者的随访,作为替代标准影像学的非侵入性技术。

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