具有神经保护活性的山楂果实中的 Sesquineolignans 衍生物。
Sesquineolignans derivatives with neuroprotective activity from the fruits of Crataegus pinnatifida.
机构信息
Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
出版信息
Fitoterapia. 2020 Jun;143:104591. doi: 10.1016/j.fitote.2020.104591. Epub 2020 Apr 8.
Ten undescribed sesquineolignans (1-10), including four sesqui-norlignans (1-4), were isolated from the fruits of Crataegus pinnatifida. Their structures were determined by comprehensive spectroscopic analyses. All compounds were examined for their neuroprotective activities against HO-induced cell injury in human neuroblastoma SH-SY5Y cells. Among them, 6 and 8 showed comparable protective effect with 79.36% and 80.72% cell viability compared with the positive control Trolox (78.64%) at 25 μM.
从山楂果实中分离得到 10 个未被描述的倍半木脂素（1-10），包括 4 个倍半新木脂素（1-4）。通过综合光谱分析确定了它们的结构。所有化合物都被检测了对人神经母细胞瘤 SH-SY5Y 细胞中 HO 诱导的细胞损伤的神经保护活性。其中，化合物 6 和 8 在 25μM 时的细胞活力分别为 79.36%和 80.72%，与阳性对照 Trolox（78.64%）相当。
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