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新评估临床队列中痴呆严重程度与住院情况的关联:南伦敦和莫兹利案例登记处。

The association between dementia severity and hospitalisation profile in a newly assessed clinical cohort: the South London and Maudsley case register.

机构信息

Epidemiology (Value Evidence and Outcomes), GSK, Brentford, London, UK

Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

出版信息

BMJ Open. 2020 Apr 12;10(4):e035779. doi: 10.1136/bmjopen-2019-035779.

Abstract

OBJECTIVES

To evaluate the risk and common causes of hospitalisation in patients with newly diagnosed dementia and variation by severity of cognitive impairment.

SETTING

We used data from a large London mental healthcare case register linked to a national hospitalisation database.

PARTICIPANTS

Individuals aged ≥65 years with newly diagnosed dementia with recorded cognitive function and the catchment population within the same geography.

OUTCOME MEASURES

We evaluated the risk and duration of hospitalisation in the year following a dementia diagnosis. In addition we identified the most common causes of hospitalisation and calculated age-standardised and gender-standardised admission ratios by dementia severity (mild/moderate/severe) relative to the catchment population.

RESULTS

Of the 5218 patients with dementia, 2596 (49.8%) were hospitalised in the year following diagnosis. The proportion of individuals with mild, moderate and severe dementia who had a hospital admission was 47.9%, 50.8% and 51.7%, respectively (p= 0.097). Duration of hospital stay increased with dementia severity (median 2 days in mild to 4 days in severe dementia, p 0.0001). After excluding readmissions for the same cause, the most common primary hospitalisation discharge diagnoses among patients with dementia were urinary system disorders, pneumonia and fracture of femur, accounting for 15%, 10% and 6% of admissions, respectively. Overall, patients with dementia were hospitalised 30% more than the catchment population, and this trend was observed for most of the discharge diagnoses evaluated. Standardised admission ratios for urinary and respiratory disorders were higher in those with more severe dementia at diagnosis.

CONCLUSIONS

Individuals with a dementia diagnosis were more likely to be hospitalised than individuals in the catchment population. The length of hospital stay increased with dementia severity. Most of the common causes of hospitalisation were more common than expected relative to the catchment population, but standardised admission ratios only varied by dementia stage for certain groups of conditions.

摘要

目的

评估新诊断痴呆患者住院的风险和常见原因,并分析认知障碍严重程度的差异。

设置

我们使用了来自伦敦大型精神保健病例登记处的数据,该数据与国家住院数据库相关联。

参与者

年龄≥65 岁、有记录的认知功能且与同一地理区域内的人群相匹配的新诊断为痴呆的个体。

结果测量

我们评估了痴呆诊断后一年内的住院风险和住院时间。此外,我们确定了最常见的住院原因,并按痴呆严重程度(轻度/中度/重度)计算了与人群相比的年龄标准化和性别标准化入院率。

结果

在 5218 例痴呆患者中,2596 例(49.8%)在诊断后一年内住院。轻度、中度和重度痴呆患者住院的比例分别为 47.9%、50.8%和 51.7%(p=0.097)。住院时间随痴呆严重程度的增加而延长(轻度痴呆患者的中位数为 2 天,重度痴呆患者为 4 天,p<0.0001)。在排除因同一原因再次入院后,痴呆患者最常见的主要住院出院诊断为泌尿系统疾病、肺炎和股骨骨折,分别占入院人数的 15%、10%和 6%。总体而言,痴呆患者的住院率比人群高 30%,而且这种趋势在评估的大多数出院诊断中都存在。在诊断时痴呆程度较重的患者中,泌尿系统和呼吸系统疾病的标准化入院率较高。

结论

与人群相比,患有痴呆症的个体更有可能住院。住院时间随痴呆严重程度的增加而增加。大多数常见的住院原因比人群预期的更为常见,但某些疾病组别的标准化入院率仅随痴呆阶段而变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a14c/7200045/1253646f9bfb/bmjopen-2019-035779f01.jpg

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