非编码 RNA 与冠状动脉疾病
Non-coding RNAs and Coronary Artery Disease.
机构信息
Center for Biomedical Network Research-Instituto de Salud Carlos III. Department of Physiology, School of Medicine, University of Valencia and INCLIVA Biomedical Research Institute, Valencia, Spain.
Department of Physiology, School of Medicine, University of Valencia, Valencia, Spain.
出版信息
Adv Exp Med Biol. 2020;1229:273-285. doi: 10.1007/978-981-15-1671-9_16.
Coronary artery disease (CAD) is the leading death cause worldwide. Non-coding RNA (ncRNA) are key regulators of genetic expression and thus can affect directly or indirectly the development and progression of different diseases. ncRNA can be classified in several types depending on the length or structure, as long non-coding RNA (lncRNA), microRNA (miRNA) and circularRNA (circRNA), among others. These types of RNA are present within cells or in circulation, and for this reason they have been used as biomarkers of different diseases, therefore revolutionizing precision medicine. Recent research studied the capability of circulating ncRNA to inform about CAD presence and predict the outcome of the disease. In this chapter we present a list of the miRNA, lncRNA and circRNA which are potential biomarkers of CAD.
冠心病（CAD）是全球主要的死亡原因。非编码 RNA（ncRNA）是基因表达的关键调节剂，因此可以直接或间接地影响不同疾病的发生和发展。ncRNA 可以根据长度或结构分为几种类型，如长非编码 RNA（lncRNA）、microRNA（miRNA）和 circularRNA（circRNA）等。这些类型的 RNA 存在于细胞内或循环中，因此它们被用作不同疾病的生物标志物，从而彻底改变了精准医学。最近的研究研究了循环 ncRNA 告知 CAD 存在并预测疾病结果的能力。在本章中，我们列出了一些可能作为 CAD 生物标志物的 miRNA、lncRNA 和 circRNA。
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