Klin Onkol. 2020 Spring;33(2):132-137. doi: 10.14735/amko2020132.
Human papillomavirus (HPV) is the worlds most widely sexually transmitted disease. HPV infection play also an important role in the etiopathogenesis of head and neck cancers, especially oropharynx.
In a prospective study of 236 patients with squamous cell carcinoma (SCC) of the upper aerodigestive tract (oral cavity, oropharynx, hypopharynx, and larynx), the incidence of p16 positivity in tumor tissue and its relationship to tumor localization, occurrence of risk factors (smoking, alcohol, and sexual behavior), histopathological findings, and stage of disease were analyzed.
Smoking and alcohol abuse were observed in 72% of patients with SCC of the upper aerodigestive tract. Risky sexual behavior was present only in the group of patients with orofaryngeal SCC (42%). Immunohistochemical staining revealed that p16 was present in 20% tumors of upper aerodigestive tract, most frequently in the oropharynx (30%). Patients with p16 positive orofaryngeal SCC were younger, and 94% of these pateints admitted risky sexual behavior. Smoking and regular alcohol consumption were more common in patients with p16 negative SCC of the oropharynx (90%).
HPV 16 infection plays a role in the etiopathogenesis of oropharyngeal carcinoma. In other locations of the upper aerodigestive tract, smoking and alcohol abuse are major risk factors. Determination of HPV status in oropharyngeal SCC is an integral part of histopathological examinations. Immunohistochemical detection of p16 protein expression in tumor tissue is considered sufficient to stratify patients into HPV positive/negative groups of oropharyngeal carcinoma. The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study. The Editorial Board declares that the manuscript met the ICMJE recommendation for biomedical papers.
人乳头瘤病毒（HPV）是世界上传播最广泛的性传播疾病。HPV 感染在头颈部癌症（尤其是口咽癌）的病因学中也起着重要作用。
在一项对 236 例上呼吸道（口腔、口咽、下咽和喉）鳞状细胞癌（SCC）患者的前瞻性研究中，分析了肿瘤组织中 p16 阳性的发生率及其与肿瘤定位、危险因素（吸烟、饮酒和性行为）、组织病理学发现和疾病分期的关系。
72%的上呼吸消化道 SCC 患者存在吸烟和酗酒。只有口咽 SCC 患者组（42%）存在危险性行为。免疫组织化学染色显示，上呼吸道肿瘤中 p16 阳性率为 20%，最常见于口咽（30%）。p16 阳性口咽 SCC 患者年龄较小，94%的患者承认有危险性行为。p16 阴性口咽 SCC 患者中吸烟和经常饮酒更为常见（90%）。
HPV 16 感染在口咽癌的发病机制中起作用。在上呼吸道的其他部位，吸烟和酗酒是主要的危险因素。确定口咽 SCC 中的 HPV 状态是组织病理学检查的一个组成部分。免疫组织化学检测肿瘤组织中 p16 蛋白的表达被认为足以将口咽癌患者分为 HPV 阳性/阴性组。作者声明他们没有与研究中使用的药物、产品或服务有关的潜在利益冲突。编辑委员会宣布，该手稿符合 ICMJE 对生物医学论文的建议。
