快速进展性痴呆相关的N型电压门控钙通道抗体脑病
Rapidly progressive dementia-associated N-type voltage-gated calcium channel antibody encephalopathy.
作者信息
Thakolwiboon Smathorn, Karukote Amputch, Sohn Gyeongmo, Duarte-Celada Walter R, Julayanont Parunyou
机构信息
Department of Neurology, Texas Tech University Health Sciences CenterLubbockTexas.
出版信息
Proc (Bayl Univ Med Cent). 2020 Jan 9;33(2):278-280. doi: 10.1080/08998280.2019.1709117. eCollection 2020 Apr.
Autoimmune encephalopathy is one of the treatable causes of rapidly progressive dementia; however, it is often underdiagnosed. Autoantibodies against voltage-gated calcium channel (VGCC) have been linked to several neurological disorders, including Lambert-Eaton syndrome, but VGCC antibody-associated encephalopathy is uncommon. Herein, we present a case of a 74-year-old woman with prominent neuropsychiatric symptoms followed by rapid cognitive decline. Extensive initial studies were nondiagnostic. Subsequently, serum N-type VGCC antibody was positive. After treatment with intravenous immunoglobulin, the patient's cognition and neuropsychiatric symptoms significantly improved.
自身免疫性脑病是快速进展性痴呆的可治疗病因之一；然而，它常常被漏诊。抗电压门控钙通道（VGCC）自身抗体与多种神经系统疾病有关，包括兰伯特-伊顿综合征，但VGCC抗体相关的脑病并不常见。在此，我们报告一例74岁女性患者，该患者有明显的神经精神症状，随后出现快速认知衰退。最初的广泛检查未明确诊断。随后，血清N型VGCC抗体呈阳性。经静脉注射免疫球蛋白治疗后，患者的认知和神经精神症状明显改善。
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