Basu Reetobrata, Kopchick John J
Ohio University Heritage College of Osteopathic Medicine (OU-HCOM), Ohio University, Athens, OH 45701, USA.
Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA.
Cancer Drug Resist. 2019 Summer;2(3):827-846. doi: 10.20517/cdr.2019.27. Epub 2019 Sep 19.
Pituitary derived and peripherally produced growth hormone (GH) is a crucial mediator of longitudinal growth, organ development, metabolic regulation with tissue specific, sex specific, and age-dependent effects. GH and its cognate receptor (GHR) are expressed in several forms of cancer and have been validated as an anti-cancer target through a large body of , and epidemiological analyses. However, the underlying molecular mechanisms of GH action in cancer prognosis and therapeutic response had been sparse until recently. This review assimilates the critical details of GH-GHR mediated therapy resistance across different cancer types, distilling the therapeutic implications based on our current understanding of these effects.
垂体来源的和外周产生的生长激素（GH）是纵向生长、器官发育、代谢调节的关键介质，具有组织特异性、性别特异性和年龄依赖性效应。GH及其同源受体（GHR）在多种癌症中表达，并已通过大量的……和流行病学分析被确认为抗癌靶点。然而，直到最近，GH在癌症预后和治疗反应中的潜在分子机制还很少见。这篇综述汇总了不同癌症类型中GH-GHR介导的治疗耐药性的关键细节，并根据我们目前对这些效应的理解提炼出治疗意义。
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