长期摄入膳食类胡萝卜素与美国女性前瞻性研究中晚年主观认知功能呈正相关。
Long-Term Intake of Dietary Carotenoids Is Positively Associated with Late-Life Subjective Cognitive Function in a Prospective Study in US Women.
机构信息
Department of Big Data and Health Science, School of Public Health, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
出版信息
J Nutr. 2020 Jul 1;150(7):1871-1879. doi: 10.1093/jn/nxaa087.
BACKGROUND
A protective association of dietary carotenoids with cognitive function has been suggested, but most studies have been relatively small with limited periods of follow-up.
OBJECTIVES
We examined prospectively long-term intakes of carotenoids in relation to subjective cognitive function (SCF), a self-reported, validated indicator of cognitive dysfunction.
METHODS
Among 49,493 female registered nurses with a mean age of 48 y in 1984, we used multinomial logistic regression to estimate the ORs and 95% CIs relating intakes of carotenoids to self-reported SCF in 2012 and 2014. Mean intakes of carotenoids were calculated from 7 repeated FFQs collected in 1984, 1986, and every 4 y afterwards until 2006. Self-reported SCF was assessed by a 7-item questionnaire on changes in memory and cognition; validity was supported by strong associations with Apolipoprotein E (APOE) ε4 genotype and concurrent cognitive function and cognitive decline measured by telephone-based neuropsychological tests. The mean values of scores assessed in 2012 and 2014 were categorized as "good" (0 points, 40.8%), "moderate" (0.5-2.5 points, 46.9%), and "poor" (3-7 points, 12.3%).
RESULTS
Higher intake of total carotenoids was associated with substantially lower odds of moderate or poor cognitive function after controlling for other dietary and nondietary risk factors and total energy intake. Comparing the top with the bottom quintile of total carotenoids, the multivariable ORs were 0.86 (95% CI: 0.80, 0.93; P-trend < 0.001) for moderate SCF and 0.67 (95% CI: 0.60, 0.75; P-trend < 0.001) for poor SCF. This lower OR was also seen for carotenoids consumed 28 y before SCF assessment. Similar associations were found for total β-carotene, dietary β-carotene, α-carotene, lycopene, lutein + zeaxanthin, and β-cryptoxanthin. The significant associations for β-cryptoxanthin, lycopene, and lutein + zeaxanthin persisted after mutual adjustment for each other.
CONCLUSIONS
Our findings support a long-term beneficial role of carotenoid consumption on cognitive function in women.
背景
膳食类胡萝卜素与认知功能之间存在保护关联，但是大多数研究规模较小，随访时间有限。
目的
我们前瞻性地研究了类胡萝卜素的长期摄入量与主观认知功能（SCF）之间的关系，SCF 是认知功能障碍的一种自我报告的、经过验证的指标。
方法
在 1984 年平均年龄为 48 岁的 49493 名注册女护士中，我们使用多项逻辑回归来估计 2012 年和 2014 年与自我报告的 SCF 相关的类胡萝卜素摄入量的 OR 和 95%CI。类胡萝卜素的平均摄入量是根据 1984 年、1986 年和之后每 4 年收集的 7 次 FFQ 计算得出的，直到 2006 年。自我报告的 SCF 通过 7 项关于记忆和认知变化的问卷进行评估；其有效性得到了强有力的支持，与载脂蛋白 E（APOE）ε4 基因型以及通过电话进行的认知功能和认知衰退测试（同时进行的认知功能和认知衰退测试）具有很强的相关性。2012 年和 2014 年评估得分的平均值分为“良好”（0 分，40.8%）、“中等”（0.5-2.5 分，46.9%）和“差”（3-7 分，12.3%）。
结果
在控制了其他饮食和非饮食风险因素以及总能量摄入后，总类胡萝卜素摄入量较高与中等或较差的认知功能的几率显著降低相关。与总类胡萝卜素的最高五分位数与最低五分位数相比，中等 SCF 的多变量 OR 为 0.86（95%CI：0.80，0.93；P 趋势 <0.001），而较差的 SCF 为 0.67（95%CI：0.60，0.75；P 趋势 <0.001）。在 SCF 评估前 28 年摄入的类胡萝卜素也存在这种较低的 OR。β-胡萝卜素、膳食β-胡萝卜素、α-胡萝卜素、番茄红素、叶黄素+玉米黄质和β-隐黄质也存在类似的关联。β-隐黄质、番茄红素和叶黄素+玉米黄质的显著关联在相互调整后仍然存在。
结论
我们的研究结果支持长期摄入类胡萝卜素对女性认知功能有益。
Zotero 插件