综述岩藻聚糖抗肿瘤策略：从生物活性物质到岩藻聚糖基系统的结构组分。

A review on fucoidan antitumor strategies: From a biological active agent to a structural component of fucoidan-based systems.

机构信息

3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics of University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, 4805-017, Barco, Guimarães, Portugal; ICVS/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal.

出版信息

Carbohydr Polym. 2020 Jul 1;239:116131. doi: 10.1016/j.carbpol.2020.116131. Epub 2020 Mar 9.

DOI:10.1016/j.carbpol.2020.116131

PMID:32414455

Abstract

Due to the severe side-effects and the toxicity to healthy tissues, cancer treatments based in chemotherapy have not fully achieved the desire outcomes so far. The use of natural compound may be of great value to develop better tolerated therapies. Fucoidan is a marine sulfated polysaccharide extracted from brown algae that, besides other biological activities, has been reported to present interesting anti-cancer potential. This review briefly introduces fucoidan chemical structure, physicochemical properties and the above-mentioned biological feature. Fucoidan usage as soluble agent presents promising results herein described for different types of cancer. Trying to enhance and optimize fucoidan usage in the cancer field, different systems, namely drug delivery, have been recently developed to target different types of cancers. This aspect will be presented in detail, highlighting the role of fucoidan on their reported or envisaged performance.

摘要

由于严重的副作用和对健康组织的毒性，基于化疗的癌症治疗迄今为止尚未完全达到预期的效果。使用天然化合物可能对开发更耐受的疗法具有重要价值。褐藻糖胶是一种从褐藻中提取的海洋硫酸多糖，除了其他生物活性外，据报道还具有有趣的抗癌潜力。本文简要介绍了褐藻糖胶的化学结构、理化性质和上述生物学特性。褐藻糖胶作为可溶性试剂的使用在本文中为不同类型的癌症描述了有前景的结果。为了增强和优化褐藻糖胶在癌症领域的应用，最近开发了不同的系统，即药物输送系统，以针对不同类型的癌症。这方面将详细介绍，重点介绍褐藻糖胶在其报道或预期的性能中的作用。