Gu Rui-Dong, Xiao Fan, Wang Lin, Sun Kai-Jian, Chen Lin-Lin
Department of Ophthalmology, the Fourth People's Hospital of Shenyang, Shenyang 110031, Liaoning Province, China.
Int J Ophthalmol. 2020 May 18;13(5):725-730. doi: 10.18240/ijo.2020.05.05. eCollection 2020.
To investigate the biocompatibility and therapeutic effects of polyetheretherketone (PEEK) on recovery of a rabbit orbital defect.
Totally 16 New Zealand rabbits were used to establish an orbital bone defect model and then randomly divided into two groups. PEEK was implanted in the experimental group. The control group was blank, and no substance was implanted. The model rabbits were sacrificed at 4 and 8wk, and examined by general observations, histology, electron microscopy, Western blotting, and real-time polymerase chain reaction.
No infection or rejection occurred after PEEK implantation, and biocompatibility was good. The relative expression of vascular endothelial growth factor (VEGF) protein in the experimental group was significantly higher than that in the control group postoperatively (<0.05). Bone defect repair in the experimental group was significantly better than that in the control group in the same period and some osteogenesis was observed.
PEEK has good biocompatibility and efficacy for the treatment of orbital bone defects in a rabbit model.
研究聚醚醚酮(PEEK)对兔眼眶缺损修复的生物相容性及治疗效果。
选用16只新西兰兔建立眼眶骨缺损模型,然后随机分为两组。实验组植入PEEK。对照组为空白组,未植入任何物质。分别于4周和8周处死模型兔,进行大体观察、组织学、电子显微镜、蛋白质免疫印迹法及实时聚合酶链反应检测。
PEEK植入后未发生感染或排斥反应,生物相容性良好。术后实验组血管内皮生长因子(VEGF)蛋白的相对表达量显著高于对照组(<0.05)。实验组同期骨缺损修复情况明显优于对照组,且观察到有一定的成骨现象。
在兔眼眶骨缺损模型中,PEEK具有良好的生物相容性及治疗效果。