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循环死亡后器官捐献的兴起:叙述性综述。

The rise of organ donation after circulatory death: a narrative review.

机构信息

National Clinical Lead for Organ Donation, NHS Blood and Transplant, Nottingham, UK.

Department of Cardiothoracic Anaesthesia, Critical Care and ECMO, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK.

出版信息

Anaesthesia. 2020 Sep;75(9):1215-1222. doi: 10.1111/anae.15100. Epub 2020 May 19.

Abstract

Solid organ transplantation saves and transforms lives. The original type of organ donation from deceased patients was controlled donation after circulatory death, previously referred to as non-heart beating organ donation. The rise of donation after circulatory death in the UK came about through advances in critical care and transplant medicine and support from several key organisations in developing a robust ethical, legal and professional framework. The transplant waiting list reached a historic peak in 2009-2010 of 8000 patients, but fell by 25% to 6000 in 2017-2018. There has also been a steady rise in the number of deceased donors and the number of donations after circulatory death. The contribution of donation after circulatory death to the total number of donations rose steadily between 2000 and 2012 and has remained about 40% since. Although the situation has improved for patients waiting for a transplant, deaths and long waits remain common. Changes to legislative, technical and peri-mortem procedures may greatly change future practices in donation after circulatory death in the UK.

摘要

实体器官移植可以拯救和改变生命。最初的捐献器官类型是来自脑死亡患者的控制型捐献,也被称为无心跳器官捐献。英国循环死亡后捐献的兴起,得益于重症监护和移植医学的进步,以及几个关键组织在建立健全的伦理、法律和专业框架方面的支持。移植等候名单在 2009-2010 年达到了 8000 名患者的历史高峰,但到 2017-2018 年下降了 25%,至 6000 名。死亡捐献者的数量和循环死亡后的捐献数量也在稳步增加。循环死亡后捐献在总捐献数量中的占比在 2000 年至 2012 年间稳步上升,此后一直保持在 40%左右。尽管等待移植的患者的情况有所改善,但死亡和长时间等待仍然很常见。立法、技术和濒死期程序的改变可能会极大地改变英国循环死亡后捐献的未来实践。

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