T 细胞记忆 B 细胞原地停留。
T-bet Memory B Cells Stay in Place.
机构信息
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Immunity. 2020 May 19;52(5):726-728. doi: 10.1016/j.immuni.2020.04.013.
Memory B cells (MBCs) expressing the transcription factor T-bet have been described in normal and dysregulated immune responses. In this issue of Immunity, Johnson et al. report that T-bet MBCs, formed in response to a primary influenza infection, contribute to protective antibody titers and persist mainly in the spleen with restricted trafficking between tissues.
表达转录因子 T-bet 的记忆 B 细胞（MBCs）已在正常和失调的免疫反应中被描述。在本期《免疫》中，Johnson 等人报告称，针对原发性流感感染形成的 T-bet MBCs 有助于保护性抗体滴度，并主要存在于脾脏中，在组织间的迁移受到限制。
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