COVID-19：血管失控。

COVID-19: the vasculature unleashed.

机构信息

Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven, Belgium.

Translational Cancer Research Unit, GZA Hospitals Sint-Augustinus, Antwerp, Belgium.

出版信息

Nat Rev Immunol. 2020 Jul;20(7):389-391. doi: 10.1038/s41577-020-0343-0.

DOI:10.1038/s41577-020-0343-0

PMID:32439870

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7240244/

Abstract

On the basis of emerging evidence from patients with COVID-19, we postulate that endothelial cells are essential contributors to the initiation and propagation of severe COVID-19. Here, we discuss current insights into the link between endothelial cells, viral infection and inflammatory changes and propose novel therapeutic strategies.

摘要

基于 COVID-19 患者的新出现证据，我们推测内皮细胞是严重 COVID-19 发病和进展的重要贡献者。在此，我们讨论内皮细胞、病毒感染和炎症变化之间的联系的最新认识，并提出新的治疗策略。