Ki67表达在结直肠癌中的临床病理意义：系统评价与Meta分析方案
Clinicopathological significance of Ki67 expression in colorectal cancer: A protocol of systematic review and meta-analysis.
作者信息
Li Jing, Liu Zhi-Ye, Yu Hai-Bo, Xue Qing, He Wen-Jie, Yu Hai-Tao
机构信息
Department of Physiology, Jiamusi University School of Basic Medical Sciences.
Department of Chemotherapy and Radiotherapy.
出版信息
Medicine (Baltimore). 2020 May;99(20):e20136. doi: 10.1097/MD.0000000000020136.
BACKGROUND
This study will investigate the diagnostic accuracy of Ki67 expression in colorectal cancer (CC).
METHODS
A comprehensive search in electronic bibliographic databases (MEDLINE, EMBASE, Cochrane Library, Web of Science, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure) will be performed from inception to the February 29, 2020 with no restrictions to the language and publication status. Two authors will examine the collected studies, extract essential data, and appraise study quality separately. If possible, we will estimate receiver operating characteristic (ROC), sensitivity and specificity by utilizing bivariate random effects and hierarchical summary ROC models.
RESULTS
This study will summarize present evidence to explore the diagnostic accuracy of Ki67 expression in CC.
CONCLUSION
The findings of this study will clarify the diagnostic accuracy of Ki67 expression in CC.
SYSTEMATIC REVIEW REGISTRATION
INPLASY202030009.
背景
本研究将调查Ki67表达在结直肠癌（CC）中的诊断准确性。
方法
将从数据库建立至2020年2月29日在电子文献数据库（MEDLINE、EMBASE、Cochrane图书馆、科学网、中国生物医学文献数据库和中国知网）中进行全面检索，对语言和出版状态不设限制。两名作者将分别检查所收集的研究、提取关键数据并评估研究质量。如有可能，我们将利用双变量随机效应模型和分层汇总ROC模型估计受试者工作特征（ROC）、敏感性和特异性。
结果
本研究将总结现有证据，以探索Ki67表达在CC中的诊断准确性。
结论
本研究的结果将阐明Ki67表达在CC中的诊断准确性。
系统评价注册
INPLASY202030009。
Zotero 插件