Department of Immunobiology and Environment Microbiology, Medical University of Gdańsk, Dębinki 7, 80-211 Gdańsk, Poland.
Independent Public Specialized Health Care Center in Lębork, Department of Internal Diseases, Węgrzynowicza 13, 84-300 Lębork, Poland.
Int J Mol Sci. 2020 May 18;21(10):3570. doi: 10.3390/ijms21103570.
The World Health Organization (WHO) has recognized obesity as one of the top ten threats to human health. It is estimated that the number of obese and overweight people worldwide exceeds the number of those who are undernourished. Obesity is not only a state of abnormally increased adipose tissue in the body, but also of increased release of biologically active adipokines. Adipokines released into the circulating blood, due to their specific receptors on the surface of target cells, act as classic hormones affecting the metabolism of tissues and organs. What is more, adipokines and cytokines may decrease the insulin sensitivity of tissues and induce inflammation and development of chronic complications. Certainly, it can be stated that in an era of a global obesity pandemic, adipokines may gain more and more importance as regards their use in the diagnostic evaluation and treatment of diseases. An extensive search for materials on the role of white, brown and perivascular fatty tissue and obesity-related metabolic and chronic complications was conducted online using PubMed, the Cochrane database and Embase.
世界卫生组织（WHO）已将肥胖认定为对人类健康的十大威胁之一。据估计，全球肥胖和超重人口的数量已经超过了营养不良人口的数量。肥胖不仅是身体中异常增加的脂肪组织的状态，也是生物活性脂联素释放增加的状态。脂联素释放到循环血液中，由于其在靶细胞表面的特定受体，作为经典激素发挥作用，影响组织和器官的代谢。更有甚者，脂联素和细胞因子可能会降低组织对胰岛素的敏感性，并引起炎症和慢性并发症的发展。当然，可以说在全球肥胖流行的时代，脂联素可能因其在疾病的诊断评估和治疗中的应用而变得越来越重要。使用 PubMed、Cochrane 数据库和 Embase 在线广泛搜索了关于白色、棕色和血管周围脂肪组织以及肥胖相关代谢和慢性并发症的作用的资料。
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