运动干预对大鼠各种疾病的影响。
Impacts of exercise intervention on various diseases in rats.
机构信息
School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.
Division of Pediatric Endocrinology, Department of Pediatrics, UCLA Children's Discovery and Innovation Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
出版信息
J Sport Health Sci. 2020 May;9(3):211-227. doi: 10.1016/j.jshs.2019.09.008. Epub 2019 Oct 28.
BACKGROUND
Exercise is considered as an important intervention for treatment and prevention of several diseases, such as osteoarthritis, obesity, hypertension, and Alzheimer's disease. This review summarizes decadal exercise intervention studies with various rat models across 6 major systems to provide a better understanding of the mechanisms behind the effects that exercise brought.
METHODS
PubMed was utilized as the data source. To collect research articles, we used the following terms to create the search: (exercise [Title] OR physical activity [Title] OR training [Title]) AND (rats [Title/Abstract] OR rat [Title/Abstract] OR rattus [Title/Abstract]). To best cover targeted studies, publication dates were limited to "within 11 years." The exercise intervention methods used for different diseases were sorted according to the mode, frequency, and intensity of exercise.
RESULTS
The collected articles were categorized into studies related to 6 systems or disease types: motor system (17 articles), metabolic system (110 articles), cardiocerebral vascular system (171 articles), nervous system (71 articles), urinary system (2 articles), and cancer (21 articles). Our review found that, for different diseases, exercise intervention mostly had a positive effect. However, the most powerful effect was achieved by using a specific mode of exercise that addressed the characteristics of the disease.
CONCLUSION
As a model animal, rats not only provide a convenient resource for studying human diseases but also provide the possibility for exploring the molecular mechanisms of exercise intervention on diseases. This review also aims to provide exercise intervention frameworks and optimal exercise dose recommendations for further human exercise intervention research.
背景
运动被认为是治疗和预防多种疾病的重要干预手段，如骨关节炎、肥胖、高血压和阿尔茨海默病。本综述总结了十年来使用各种大鼠模型进行的运动干预研究，以更好地了解运动带来的影响背后的机制。
方法
我们使用 PubMed 作为数据源。为了收集研究文章，我们使用以下术语创建搜索：（exercise [标题] 或 physical activity [标题] 或 training [标题]）AND （rats [标题/摘要] 或 rat [标题/摘要] 或 rattus [标题/摘要]）。为了最好地涵盖目标研究，出版物日期限制在“11 年内”。根据运动模式、频率和强度，对用于不同疾病的运动干预方法进行了分类。
结果
收集的文章分为与 6 个系统或疾病类型相关的研究：运动系统（17 篇文章）、代谢系统（110 篇文章）、心脑血管系统（171 篇文章）、神经系统（71 篇文章）、泌尿系统（2 篇文章）和癌症（21 篇文章）。我们的综述发现，对于不同的疾病，运动干预大多有积极的影响。然而，通过使用针对疾病特征的特定运动模式，可以达到最强的效果。
结论
作为一种模式动物，大鼠不仅为研究人类疾病提供了便利的资源，还为探索运动干预对疾病的分子机制提供了可能性。本综述还旨在为进一步的人类运动干预研究提供运动干预框架和最佳运动剂量建议。
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